Naphazolin

Bezeichnung:Naphazolin

CAS-Nr835-31-4

Englisch Name:Naphazoline

CBNumberCB2414016

SummenformelC14H14N2

Molgewicht210.27

MOL-Datei835-31-4.mol

Synonyma

Naphazolin

Naphazolin physikalisch-chemischer Eigenschaften

Schmelzpunkt	254 °C
Siedepunkt	339.81°C (rough estimate)
Dichte	1.1063 (rough estimate)
Brechungsindex	1.6180 (estimate)
storage temp.	2-8°C
pka	pKa 10.35 ± 0.02(H2O,t =25,Iundefined) (Uncertain)
CAS Datenbank	835-31-4(CAS DataBase Reference)
NIST chemische Informationen	Naphazoline(835-31-4)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	NJ4375000

Naphazoline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Originator
Privine,Ciba,US,1942
Verwenden
Naphazoline is used in severe rhinitis associated with colds, allergic reactions, and severe and chronic inflammatory conditions, in particular for inflammation of the antrum of Highmore as well as for stopping nosebleeds.
Verwenden
Adrenergic (vasoconstrictor).
Definition
ChEBI: 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes.
Manufacturing Process
2.7 parts of naphthyl-(1)-acetiminoethylether hydrochloride of the formula (produced from naphthyl-(1)-acetonitrile and methanol) are dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the whole is heated to gentle boiling while passing nitrogen through it and simultaneously stirring until ammonia escapes no longer. The alcohol is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring is continued for some time whereby the imidazoline base is dissolved in benzene. The benzene residue is recrystallized several times from toluene.
Trademarks
Albalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).
Therapeutic Function
Nasal decongestant
Synthese
Naphazoline, 2-(1-naphthylmethyl)-2-imidazoline (11.1.36), is synthesized from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester (11.1.35), and undergoes further heterocyclization into the desired imidozoline derivative (11.1.36) upon reaction with ethylendiamine [40].

Naphazoline Upstream-Materialien And Downstream Produkte

Naphazolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

835-31-4, Naphazoline Verwandte Suche:

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