Alvespimycin Struktur

Alvespimycin

Bezeichnung:Alvespimycin

CAS-Nr467214-20-6

Englisch Name:Alvespimycin

CBNumberCB7972636

SummenformelC32H48N4O8

Molgewicht616.75

MOL-Datei467214-20-6.mol

Alvespimycin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>270°C (dec.)
Siedepunkt	810.5±65.0 °C(Predicted)
Dichte	1.20
storage temp.	Desiccate at -20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	8.48±0.70(Predicted)
Farbe	Very Dark Purple

Sicherheit

HS Code

29419090

Gefahreninformationscode (GHS)

Alvespimycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC₅₀ = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.
Chemische Eigenschaften
Solid
Verwenden
17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90.
Verwenden
The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
Verwenden
17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
Definition
ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.
Biologische Aktivität
Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Alvespimycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

467214-20-6, Alvespimycin Verwandte Suche:

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