2-Chlor-alpha-(2-(dimethylamino)-ethyl)-alpha-phenylbenzolmethanol-hydrochlorid

Bezeichnung:2-Chlor-alpha-(2-(dimethylamino)-ethyl)-alpha-phenylbenzolmethanol-hydrochlorid

CAS-Nr511-13-7

Englisch Name:2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE

CBNumberCB7744592

SummenformelC17H21Cl2NO

Molgewicht326.26

MOL-Datei511-13-7.mol

Synonyma

Clofedanolhydrochlorid

2-Chlor-alpha-(2-(dimethylamino)-ethyl)-alpha-phenylbenzolmethanol-hydrochlorid

2-Chlor-alpha-(2-(dimethylamino)-ethyl)-alpha-phenylbenzolmethanol-hydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	190-191°
storage temp.	Hygroscopic, Refrigerator, under inert atmosphere
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Stabilität	Hygroscopic
CAS Datenbank	511-13-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	36/37/39-45
RIDADR	3249
RTECS-Nr.	DC7600000
HazardClass	6.1(b)
PackingGroup	III
Toxizität	LD50 orally in rats: 350 mg/kg; s.c. in mice: 95 mg/kg (Lorenz)

Gefahreninformationscode (GHS)

2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Originator
Abehol,Pliva
Verwenden
A centrally-acting cough suppressant. It has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.
Definition
ChEBI: Chlophedianol hydrochloride is a diarylmethane.
Manufacturing Process
To a suspension of 330.0 g of sodamide (moistened with toluene) in 1500 ml of absolute ether, a solution of 1080.0 g of o-chlorobenzophenone and 350.0 g of acetonitrile in 3500 ml of absolute ether was gradually added dropwise, with stirring, such that the reaction temperature adjusted itself to 28°-30°C. The reaction mixture was stirred for 12 to 15 h at room temperature and was then added carefully to some ice water. The resulting solution was extracted 3 times with ether. The ether solution was washed with water, dried over Na2SO4, filtered, and finally concentrated. When 1 L of petroleum ether was added, 1240.0 g (96% of theoretical) of β-phenyl-β-o-chlorophenylhydroacrylonitrile (melting point 90°-92°C) precipitated.
500.0 g of the β-phenyl-β-o-chlorophenyl-hydroacrylonitrile were dissolved in 3 L of methanol and hydrogenated in the presence of 50.0 g of Raney cobalt at a temperature of 60°-70°C and a pressure of 80-85 ATM. Two moles of hydrogen were absorbed, and after separation of the methanolic solution from the catalyst, 450.0 g of 1-o-chlorophenyl-1-phenyl-3-aminopropanol-1 of melting point 117°C were obtained.
Catalytic methylation of 1-o-chlorophenyl-1-phenyl-3-aminopropanol-1 (hydrogenation in the presence of 2.2 mol of formaldehyde in aqueous methanol with Raney nickel catalyst) yielded 450.0 g of l-o-chlorophenyl-1- phenyl-3 dimethylaminopropanol-1 of melting point 120°C.
In practice it is usually used as hydrochloride.
Trademarks
Ulo (3M Pharmaceuticals).
Therapeutic Function
Antitussive

2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

2-Chlor-alpha-(2-(dimethylamino)-ethyl)-alpha-phenylbenzolmethanol-hydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

511-13-7, 2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE Verwandte Suche:

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