Methyl 2-amino-5-bromonicotinate

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H319：Verursacht schwere Augenreizung.

• Sicherheit

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Methyl 2-amino-5-bromonicotinate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Methyl 2-Amino-5-bromonicotinate is a chemical reagent used in the synthesis of pharmaceutical agents.

• Synthese

  

  14667-47-1

  

  50735-34-7

  To a stirred solution of methyl 2-aminopyridine-3-carboxylate (2 g, 13.15 mmol) and sodium bicarbonate (2.2 g, 26.31 mmol) in dichloromethane (30 mL) was slowly added a dichloromethane solution of bromine dropwise (1.01 mL bromine dissolved in 20 mL dichloromethane). The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with sodium bisulfite solution (50 mL). The reaction mixture was extracted with dichloromethane (2 x 40 mL) and the combined organic phases were washed with brine (40 mL) and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give methyl 2-amino-5-bromopyridine-3-carboxylate as a yellow solid (3 g, 99% yield).LCMS m/z (79Br/81Br) 231/233 (M+H)+.

• Einzelnachweise

  [1] Patent: US2017/29420, 2017, A1. Location in patent: Paragraph 0034

Methyl 2-amino-5-bromonicotinate Upstream-Materialien And Downstream Produkte

Methyl 2-amino-5-bromonicotinate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(175)Suppliers

50735-34-7, Methyl 2-amino-5-bromonicotinate Verwandte Suche: