3β-Hydroxyurs-12-en-28-sure Produkt Beschreibung

Ursolic acid Struktur
77-52-1
  • CAS-Nr.77-52-1
  • Bezeichnung:3β-Hydroxyurs-12-en-28-sure
  • Englisch Name:Ursolic acid
  • Synonyma:3β-Hydroxyurs-12-en-28-sure
    URSON;MALOL;PRUNOL;Ursolic;NSC-4060;Masterin;Merotaine;Neoage UR;MICROMEROL;NSC 167406
  • CBNumber:CB7470516
  • Summenformel:C30H48O3
  • Molgewicht:456.7
  • MOL-Datei:77-52-1.mol
3β-Hydroxyurs-12-en-28-sure physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :292 °C (dec.)(lit.)
  • alpha  :59 º (c=0.3, pyridine)
  • Siedepunkt: :502.79°C (rough estimate)
  • Dichte :1.0261 (rough estimate)
  • Brechungsindex :1.4940 (estimate)
  • storage temp.  :2-8°C
  • Aggregatzustand :Crystalline Powder or Needles
  • Farbe :White to off-white
  • Wasserlöslichkeit :insoluble
  • Merck  :14,9890
  • BRN  :2228563
  • CAS Datenbank :77-52-1(CAS DataBase Reference)
  • EPA chemische Informationen :Urs-12-en-28-oic acid, 3-hydroxy-, (3.beta.)-(77-52-1)
Sicherheit
  • Kennzeichnung gefährlicher :Xi
  • R-Sätze: :36/37/38
  • S-Sätze: :24/25-36-26
  • WGK Germany  :-
  • RTECS-Nr. :YU9520000
  • F  :10-23
  • HS Code  :29181990

Ursolic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S24/25:Berührung mit den Augen und der Haut vermeiden.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  • Chemische Eigenschaften white to light yellow crystal powde
  • Verwenden A Triterpene acid used in cosmetics, that also has STAT3 pathway inhibiting properties.
  • Verwenden ursolic acid helps maintain the look and feel of the skin, acts as a perfume and helps mask odor. Therapeutic benefits in skin care include anti-inflammatory activity. ursolic acid has demonstrated anti-microbial, anti-bacterial, and anti-fungal action as well.
  • Definition ChEBI: A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
  • Anticancer Research It is a triterpenoid, derived from basil, and suppresses the activation of NF-κB byinhibiting a kinase that activates NF-κB(IKK) (Aggarwal and Shishodia 2004). It suppresses tumorigenesis, tumor promotion, and angiogenesis by downregulationof the expression of lipoxygenases (LOX), MMP-9, and COX-2. It is reported toinduce apoptosis in breast cancer, melanoma, hepatoma, prostate cancer, andacute myelogenous leukemia by preventing replication of DNA, inhibition of proteintyrosine kinases, activation of caspases, induction of calcium release, anddownregulating apoptosis gene cellular inhibitor. Ursolic acid inhibits IκBαkinase activity, degradation of IκBα, phosphorylation, NF-κB-dependent reportergene expression, p65 nuclear translocation, and p65 phosphorylation. Inhibitionof NF-κB leads to the reduction of cyclin D1, COX-2, and MMP9 expression.This downregulates STAT-3 activation and its regulated gene products such ascyclin D1, Mcl-1, Bcl-xL, survivin, Bcl-2, and VEGF. It also induces the expressionof tyrosine phosphatase SHP-1 protein and of mRNA (Aggarwal et al. 2008;Hsu et al. 2004).
  • Cytotoxicity IC50 (μg/mL): 6.7 (518A2), 5.3 (A2780), 7(A549), 6.4 (FaDu), 4.8 (HT29), 5.8(MCF-7), 8.5 (NIH3T3) (Wiemann et al.2016)
    IC50 (μg/mL): 12.38 (MGC-803),17.12(HCT-116), 13.39 (T24), 13.81(HepG2), 16.36 (A549), >45.7 (HL-7702)(Hua et al. 2015).
Ursolic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3β-Hydroxyurs-12-en-28-sure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global(370)Suppliers
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77-52-1, Ursolic acid Verwandte Suche:
  • factory price Ursolic acid 77-52-1
  • Ursolic Acid 25%
  • 3beta-hydroxyurs-12-en-28-oic acid
  • (1S,2R,4AS,6AS,6BR,8AR,10S,12AR,12BR,14BS)-10-HYDROXY-1,2,6A,6B,9,9,12A-HEPTAMETHYL-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-ICOSAHYDROPICENE-4A-CARBOXYLIC ACID
  • MALOL
  • PRUNOL
  • SAGE EXTRACT
  • MICROMEROL
  • URSOLIC ACID
  • URSON
  • 3β-Hydroxy-12-ursen-28-ic acid
  • URSOLIC ACID MINIMUM 90%
  • URSOLIC ACID, 90+%
  • URSONIC ACID, 98+% NATURAL STANDARD
  • URSOLIC ACID, 4%
  • URSOLIC ACID, 99+% HPLC
  • UROPORPHYRIN I ETHYL ESTER FROM BOVINE PROPHYRIC URINE
  • URSOLIC ACID, 98+%
  • LoquatLeafExtract-UrsolicAcid25-98%
  • Ursolic
  • Urs-12-en-28-oic acid, 3-hydroxy-, (3.beta.)-
  • (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
  • URSOLIC ACID(P)
  • URSOLIC ACID(RG)
  • URSOLIC ACID hplc
  • Urs-12-en-28-oic acid, 3-hydroxy-, (3)-
  • URSOLIC ACID (SAGE EXTRACT)
  • URSOLIC ACID (LIGUSTRUM LUCIDUM AIT)
  • Ursolic Acid - CAS 77-52-1 - Calbiochem
  • URSOLIC ACID WITH HPLC
  • (3beta)-3-Hydroxy-urs-12-en-28-oic acid
  • URSOLIC ACID,95%
  • 3β-Hydroxyurs-12-en-28-oic acid
  • NSC-4060
  • beta-Ursolic Acid
  • Ursolic acid,3β-Hydroxy-12-ursen-28-ic acid
  • Merotaine
  • Neoage UR
  • NSC 167406
  • UrsolisoMe
  • Bungeolic Acid
  • Ursolic acid (Malol)
  • ForMosolic acid
  • Forucosolic acid
  • Masterin
  • 3-Hydroxy-12-ursen-28-oicacid
  • Ursolic Acid SynonyMs: 3beta-Hydroxyurs-12-en-28-oic acid
  • Ursolic Acid 77-52-1
  • Ursolic acid 3beta-Hydroxyurs-12-en-28-oic acid
  • (1S,2R,4aS,6aS,6bR,12aR,12bR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
  • Ursoliic acid
  • (3beta)-urs-12-en-28-oicaci
  • 3-hydroxy-,(3.beta.)-Urs-12-en-28-oicacid
  • 3BETA-HYDROXY-12-URSEN-28-IC ACID
  • 3BETA-HYDROXY-12-URSEN-28-OIC ACID
  • 3B-HYDROXYURS-12-EN-28-OIC ACID
  • 77-52-1
  • C30H48O3