α-Hydroxy-o-tolyl-β-D-glucopyranosid

Bezeichnung:α-Hydroxy-o-tolyl-β-D-glucopyranosid

CAS-Nr138-52-3

Englisch Name:D-(-)-Salicin

CBNumberCB2349192

SummenformelC13H18O7

Molgewicht286.28

MOL-Datei138-52-3.mol

Synonyma

α-Hydroxy-o-tolyl-β-D-glucopyranosid

α-Hydroxy-o-tolyl-β-D-glucopyranosid physikalisch-chemischer Eigenschaften

Schmelzpunkt	196-202 °C
Siedepunkt	388.65°C (rough estimate)
alpha	-61.5 º (c=5, water)
Dichte	1.4340
Brechungsindex	-62 ° (C=3, H2O)
storage temp.	2-8°C
Löslichkeit	36g/l
Aggregatzustand	Fine Crystalline Powder
pka	12.80±0.70(Predicted)
Farbe	White
Wasserlöslichkeit	36 g/L (15 ºC), 250 g/L (60 ºC)
Merck	14,8324
BRN	89593
Stabilität	Stable, but light sensitive. Incompatible with strong oxidizing agents.
InChIKey	NGFMICBWJRZIBI-MICYEWLZSA-N
LogP	-1.232 (est)
CAS Datenbank	138-52-3(CAS DataBase Reference)
NIST chemische Informationen	Salicin(138-52-3)
EPA chemische Informationen	.beta.-D-Glucopyranoside, 2-(hydroxymethyl)phenyl (138-52-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	43
S-Sätze:	36/37-37-24/25-36
WGK Germany	3
RTECS-Nr.	LZ5901700
F	3-10
TSCA	Yes
HS Code	29389090

Gefahreninformationscode (GHS)

D-(-)-Salicin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S37:Geeignete Schutzhandschuhe tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white crystals or powder
Verwenden
D-(-)-Salicin has been used:
- to study its in vitro anticoagulant and antiplatelet activities
- as a standard in high performance liquid chromatography method (HPLC) for quantitation of salicin from willow plant
- as a tastant in taste threshold assay
- as a constituent of nutrient agar-salicin medium for selective isolation of Lactobacillus paracasei
Verwenden
Standard substrate in evaluating enzyme Preparations contg b-glucosidase: Weidenhagen, Z. Ver. Zucker-Ind. 79, 591 (1929).
Verwenden
analgesic, antipyretic
Verwenden
H1 antihistamine (nonsedating)
Definition
ChEBI: An aryl beta-D-glucoside that is the beta-D-glucoside of the phenolic hydroxy group of salicyl alcohol.
Allgemeine Beschreibung
Salicin is a non-phenolic glucosidic compound extracted from meadowsweet (Filipendula ulmaria L). It is majorly used as a substitute for quinine. Salicin can be used as a therapeutic for patients suffering from rheumatic fever. Salicin acts a metabolic precursor for salicylic acid. It is a novel phytochemical that exhibits immunological cross functions in plants and humans. Salicin facilitates growth and reproduction in plants. In addition, It also protects plants against biotic and abiotic stress.
Biochem/physiol Actions
D-(?)-Salicin exerts anti-rheumatism and anti-inflammatory activities. It inhibits lipopolysaccharide (LPS) induced inflammation in in vitro and in vivo studies. It regulates different signaling pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK). It also regulates cytokines concentration such as tumor necrosis factor-alpha(TNF-α), interleukin-1β, interleukin-6, and interleukin-10.
läuterung methode
Crystallise D(-)-salicin from EtOAc, EtOH or water and sublime it at 190-195o/12mm. [Armour et al. J Chem Soc 412 1961, IR: Pearl & Darling J Org Chem 24 731 1959, Beilstein 17 III/IV 2986, 17/7 V 113.]

D-(-)-Salicin Upstream-Materialien And Downstream Produkte

α-Hydroxy-o-tolyl-β-D-glucopyranosid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

138-52-3, D-(-)-Salicin Verwandte Suche:

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