Cefditoren pivoxil

Bezeichnung:Cefditoren pivoxil

CAS-Nr117467-28-4

Englisch Name:Cefditoren pivoxil

CBNumberCB7377697

SummenformelC25H28N6O7S3

Molgewicht620.72

MOL-Datei117467-28-4.mol

Cefditoren pivoxil physikalisch-chemischer Eigenschaften

Schmelzpunkt	207-209°C
alpha	D20 -48.5° (c = 0.5 in methanol)
Dichte	1.55±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Heated)
Aggregatzustand	Solid
pka	8.08±0.60(Predicted)
Farbe	Off-White to Pale Yellow
Merck	14,1921
CAS Datenbank	117467-28-4(CAS DataBase Reference)

Sicherheit

RTECS-Nr.	XI0367800
HS Code	2941.90.3000

Gefahreninformationscode (GHS)

Cefditoren pivoxil Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Cefditoren pivoxil is an orally bioavailable prodrug form of the broad-spectrum cephalosporin antibiotic cefditoren. Cefditoren pivoxil is hydrolyzed by intestinal wall esterases to form cefditoren. Cefditoren pivoxil is effective against systemic S. aureus, E. coli, K. pneumoniae, P. mirabilis, or S. marcescens infections in mice with ED₅₀ values of 10, 2.5, 11, 4.4, and 11 mg/kg, respectively. Formulations containing cefditoren pivoxil were previously used in the treatment of acute bacterial exacerbations of chronic bronchitis and community-acquired pneumonia.
Beschreibung
Cefditoren pivoxil is an orally active third generation cephalosporin introduced in Japan as a treatment for a broad range of bacterial infections including dermatological and other community acquired infections. Cefditoren pivoxil is reported to have a broad spectrum of activity against both Gram-positive and Gramnegative bacteria, more potent than many other existing agents of its class. In particular, it shows the highest therapeutic activity against S. pneumoniae and S. marcescens infections. It exhibits resistance to β-lactamase hydrolysis typical of third generation cephalosporins. As a prodrug of cefditoren, it is readily absorbed through GI tract and has low toxicity and side effects.
Chemische Eigenschaften
Off-White Powder
Originator
Meiji Seika (Japan)
Verwenden
antidepressant
Verwenden
An antibacterial. Third generation cephalosporin
Verwenden
Cefditoren Pivoxil is an antibacterial and is a third generation cephalosporin.
Definition
ChEBI: The pivaloyloxymethyl ester prodrug of cefditoren.
Manufacturing Process
A mixture of THF (250 ml) and water (150 ml) was stirred under inert atmosphere. At 0°-1°C, 7-amino-3-[(Z)-2-(methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid (25.0 g) and 2-mercapto-5-phenyl-1,3,4- oxadiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino acetate (33.3 g) were added. Triethylamine (10.5 g) was slowly added to reaction by maintaining the pH between 7.5 to 8.5. The reaction was monitored by HPLC. After 4-5 hrs., the reaction mixture was extracted by methylene chloride. The aqueous layer is subjected for charcoal (0.125 g) treatment. Ethylacetate was added to the filtrate and the solution was acidified with diluted HCl at 10°C to pH 3.0. The solid separated was filtered, washed with water and ethylacetate and then dried under vacuum at 40-45°C to get 3-[(Z)-2-(4-methyl-5-thiazolyl)vinyl]-7- [(Z)-(2-aminothiazolyl-4-yl)-2-(methoxyimino)acetamido]-3-cephem-4- carboxylic acid (Cefditoren acid), 35.0 g (yield 90%), HPLC (purity)=96-98%.
In practice it is often used as Cefditoren pivoxil.
Trademarks
Meiact
Therapeutic Function
Antibiotic
Antimicrobial activity
It exhibits good activity against staphylococci, streptococci (but not enterococci), H. influenzae and M. catarrhalis, including β-lactamase-producing strains. Isolates of Str. pneumoniae exhibiting reduced susceptibility to penicillin are less susceptible (MIC 0.125–2 mg/L). Most enterobacteria, including many Enterobacter, Citrobacter, Serratia and Proteus spp., are susceptible. It is not active against Ps. aeruginosa, Sten. maltophilia or atypical respiratory pathogens such as Chlamydophila pneumoniae and M. pneumoniae. It is stable to staphylococcal and common enterobacterial β-lactamases.
Pharmakokinetik
Oral absorption: c. 70%
C_{max 200 mg oral: c. 1.8 mg/L after 1.5–3 h

Plasma half-life: 0.8–1.3 h

Volume of distribution: 9.3 L

Plasma protein binding: 88%

After oral administration the pivaloyl ester is rapidly cleaved
by esterases in the gut wall. Ingestion with food improves
the bioavailability. Plasma concentrations are raised in
elderly patients. There is no accumulation on repeated
dosing.

It is excreted unchanged in the urine with a half-life of
around 1.5 h, achieving a concentration of 150–200 mg/L
within 4 h. Dosage adjustment is recommended in patients
with deteriorating renal function.}
Clinical Use
It has been advocated for community-acquired upper and lower respiratory tract infections and skin infections.
Nebenwirkungen
In common with other pivoxil esters it may cause carnitine deficiency. Other side effects are those common to cephalosporins, mainly gastrointestinal disturbance.

Cefditoren pivoxil Upstream-Materialien And Downstream Produkte

Cefditoren pivoxil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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