Mafenid Produkt Beschreibung

4-(AMINOMETHYL)BENZENESULFONAMIDE Struktur
138-39-6
  • CAS-Nr.138-39-6
  • Bezeichnung:Mafenid
  • Englisch Name:4-(AMINOMETHYL)BENZENESULFONAMIDE
  • Synonyma:Mafenid
    Homosul;Homonal;Emilene;Mesudin;Maphenid;Malfamin;Mesudrin;Ambamide;Neofamid;Septicid
  • CBNumber:CB7347830
  • Summenformel:C7H10N2O2S
  • Molgewicht:186.23
  • MOL-Datei:138-39-6.mol
Mafenid physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :177-178℃ (decomposition)
  • Siedepunkt: :382.0±44.0 °C(Predicted)
  • Dichte :1.345±0.06 g/cm3(Predicted)
  • storage temp.  :Sealed in dry,2-8°C
  • pka :10.16±0.10(Predicted)
Sicherheit
  • HazardClass  :IRRITANT

4-(AMINOMETHYL)BENZENESULFONAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

  • Originator Sulfamylon,Winthrop,US,1949
  • Verwenden antibacterial
  • Manufacturing Process For the preparation of mafenide 50 g of acetylbenzylamine are introduced while stirring into 150 cc of chlorosulfonic acid, whereby the temperature is kept below 40°C by external cooling. After several hours' storing at ordinary temperature the mixture is heated for 1 hour in the boiling water-bath and after cooling, poured on to ice. Thereupon the 4-acetylaminoethylbenzenesulfonic acid chloride precipitates at first in an oily form, but solidifies after short stirring to crystals. The product sucked off and washed with cold water is introduced into a 10% aqueous ammonia solution. Thereby dissolution takes place while heating and after a short time the 4- acetylaminomethyl-benzenesulfonic acid amide precipitates in a crystalline form. After heating to 70°C for 30 minutes the solution is cooled, filtered with suction and washed out. The product is obtained when recrystallized from water or dilute alcohol in colorless crystals melting at 177%. It is readily soluble in warm water, extremely readily soluble in dilute sodium hydroxide solution.
  • Trademarks Sulfamylon (Sterling Winthrop).
  • Therapeutic Function Antibacterial
  • Pharmazeutische Anwendungen p-Aminomethylbenzene sulfonamide; Sulfamylon.
    A topical agent formerly used extensively in burns, especially for its action in suppressing Ps. aeruginosa. It is rapidly absorbed through burned skin and is unusual in that it is not neutralized by p-aminobenzoic acid or by tissue exudates. Disadvantages of its use are local pain and burning, a variety of allergic reactions including erythema multiforme and its capacity to inhibit carbonic anhydrase, necessitating careful observation to detect the development of metabolic acidosis. Its metabolite, p-carboxybenzene sulfonamide, also inhibits carbonic anhydrase but has no antibacterial activity. Mafenide propionate was formerly used in ophthalmic preparations.
  • Chemical Synthesis Maphenide, n-(aminomethyl)-benzenesulfamide (33.1.48), is structurally somewhat different from all drugs examined above in that the amino group in the p-position to the sulfonamide group is distanced from the benzene ring by one methyl group. This drug is synthesized from N-benzylacetamide, subsequent reaction of which with chlorosulfonic acid and then with ammonia gives 4-(acetamidomethyl)-benzene-sulfonamide (33.1.47). Hydrolyzing this product with a base gives maphenid.


    Synonyms of this drug are marfanil, mezudin, ambamide, septicid, and others.
4-(AMINOMETHYL)BENZENESULFONAMIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Mafenid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global(52)Suppliers
  • Firmenname:Hubei Jusheng Technology Co.,Ltd.
  • Telefon:86-18871470254
  • Fax:027-59599243
  • E-Mail:linda@hubeijusheng.com
  • Land:CHINA
  • Produktkatalog:28229
  • Edge Rate:58
  • Firmenname:Alchem Pharmtech,Inc.
  • Telefon:8485655694
  • Fax:
  • E-Mail:sales@alchempharmtech.com
  • Land:United States
  • Produktkatalog:63726
  • Edge Rate:58
  • Firmenname:Zhuozhou Wenxi import and Export Co., Ltd
  • Telefon:+8613111626072 (WhatsApp)
  • Fax:Wechat: +8613111626072 Wickr me: waynehu
  • E-Mail:zzwenxi@126.com
  • Land:CHINA
  • Produktkatalog:13187
  • Edge Rate:58
  • Firmenname:Dideu Industries Group Limited
  • Telefon:029-88380327
  • Fax:
  • E-Mail:Service@dideu.com
  • Land:CHINA
  • Produktkatalog:29986
  • Edge Rate:58
  • Firmenname:Amadis Chemical Company Limited
  • Telefon:0086-571-89925085
  • Fax:0086-571-89925065
  • E-Mail:sales@amadischem.com
  • Land:China
  • Produktkatalog:132148
  • Edge Rate:58
  • Firmenname:J & K SCIENTIFIC LTD.
  • Telefon:400-666-7788 010-82848833-
  • Fax:86-10-82849933
  • E-Mail:jkinfo@jkchemical.com;market6@jkchemical.com
  • Land:China
  • Produktkatalog:96815
  • Edge Rate:76
  • Firmenname:Hangzhou Sage Chemical Co., Ltd.
  • Telefon:0571-86818502
  • Fax:Pls mail us for more information!
  • E-Mail:info@sagechem.com
  • Land:China
  • Produktkatalog:10277
  • Edge Rate:58
138-39-6, 4-(AMINOMETHYL)BENZENESULFONAMIDE Verwandte Suche:
  • -Amino-p-toluenesulfonamide
  • Benzamsulfonamide
  • Benzenesulfonamide, 4-(aminomethyl)-
  • Emilene
  • Homonal
  • Homosul
  • Homosulfamine
  • Homosulfanilamide
  • Malfamin
  • Maphenid
  • Maphenide
  • Marprontil
  • Mesudin
  • Mesudrin
  • 4-Homosulfanilamide
  • alpha-Amino-p-toluenesulfonamide
  • Ambamide
  • Neofamid
  • NSC-34632
  • p-(Aminomethyl)benzenesulfonamide
  • Paramenyl
  • p-Toluenesulfonamide, alpha-amino-
  • Septicid
  • Sulfamylon
  • RARECHEM AL BW 0818
  • alpha-aminotoluene-4-sulphonamide
  • 4-AMINOMETHYLBENZENE SULPHONAMIDE
  • 4-(AMINOMETHYL)BENZENESULFONAMIDE
  • Benzenesulfonamide, 4-(aminomethyl)- (9CI)
  • mafenide,sdulfmylon,SML
  • 4-AMINOMETHYLBENZENESULFONAMIDE, 95+%
  • p-Aminomethylbenzenesulfonylamide
  • 4-(aMinoMethyl)benzene-1-sulfonaMide
  • p-Sulfamoylbenzylamine
  • alpha-Amino-p-toluenesulfonamide monoacetate
  • Benzenesulfonamide, 4-(aminomethyl)-, monoacetate
  • Mafenide acetate (JAN/USP)
  • Mafenide acetate [USAN:JAN]
  • p-Toluenes
  • Sulfamilon
  • Sulfamylon (TN)
  • Winthrocine
  • 4-(AMINOMETHYL)BENZENESULFONAMIDE USP/EP/BP
  • 138-39-6
  • SULFAMYLON
  • SULFONAMIDE