ANTIMYCIN A

Bezeichnung:ANTIMYCIN A

CAS-Nr1397-94-0

Englisch Name:ANTIMYCIN A

CBNumberCB7286265

SummenformelC28H40N2O9

Molgewicht548.6252

MOL-Datei1397-94-0.mol

ANTIMYCIN A physikalisch-chemischer Eigenschaften

Schmelzpunkt	141-142℃
Siedepunkt	598.78°C (rough estimate)
Dichte	1.6009 (rough estimate)
Brechungsindex	1.5800 (estimate)
storage temp.	2-8°C
Löslichkeit	Ethanol: soluble
Aggregatzustand	White to faint yellow powder.
Wasserlöslichkeit	Soluble in 100% ethanol. Insoluble in water.
Sensitive	Light Sensitive
Stabilität	Light Sensitive
EPA chemische Informationen	Antimycin A (1397-94-0)

Sicherheit

Kennzeichnung gefährlicher	T,N
R-Sätze:	25-50
S-Sätze:	26-36/37/39-45-61
RIDADR	UN 3462 6.1/PG 2
WGK Germany	3
RTECS-Nr.	CD0350000
F	18
HazardClass	6.1(a)
PackingGroup	II
HS Code	2941900000
Giftige Stoffe Daten	1397-94-0(Hazardous Substances Data)
Toxizität	LDLo orl-rat: 30 mg/kg 85ERAY 2,1078,78

Gefahreninformationscode (GHS)

ANTIMYCIN A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Antimycin (A3 C26H36N2O9) and (AntimycinA1) C28H40N2O9 are crystalline solids. Molecularweight= 512.8 (A); 520.64 (A3-); 506.6 (A4-); Freezing/Melting point= 170°175℃; 149°150℃ (A1); 174°175℃(A3). They are complex 9-membered (2 oxygens and 7 carbons) ring derivatives with complex side chains. HazardIdentification (based on NFPA-704 M Rating System):Health 3, Flammability 0, Reactivity 0. Practically insolublein water.
Chemische Eigenschaften
Antimycin (A3C26H36N2O9) and (Antimycin A1) C28H40N2O9 are crystalline solids.
Verwenden
antifungal, antiviral, interferes in cytochrome oxidation
Verwenden
Antimycin A is used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise.
Verwenden
Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.
Definition
ChEBI: Antimycin A is a nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison. It has a role as a piscicide, a mitochondrial respiratory-chain inhibitor and an antifungal agent. It is a macrodiolide, a member of formamides, a member of benzamides and a member of phenols.
Allgemeine Beschreibung
Solid. Specific uses for ANTIMYCIN A were not found. ANTIMYCIN A1,and ANTIMYCIN A3 are reported as antibiotics produced by Streptomyces for use as a fungicide and possibly as an insecticide and miticide. Registered only as a pesticide in the U.S.
Brandgefahr
When heated to decomposition, ANTIMYCIN A emits toxic fumes of oxides of nitrogen.
Landwirtschaftliche Anwendung
Fungicide, Piscicide: A U.S. EPA restricted Use Pesticide (RUP). May also be used as an insecticide.
Handelsname
FINTROL®; VIROSIN®
Sicherheitsprofil
Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes.When heated to decomposition it emits toxic fumes ofNOx.
mögliche Exposition
Specific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.
Erste Hilfe
f this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immedi ately with soap and water. Seek medical attention258 Antimycin Aimmediately. If this chemical has been inhaled, removefrom exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Lager
Color Code—Blue: Health Hazard/Poison: Store ina secure poison location. Prior to working with this chemicalyou should be trained on its proper handling and storage.
Versand/Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

1397-94-0, ANTIMYCIN A Verwandte Suche:

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