Tegaserod maleate Struktur

Tegaserod maleate

Bezeichnung:Tegaserod maleate

CAS-Nr189188-57-6

Englisch Name:Tegaserod maleate

CBNumberCB7225422

SummenformelC20H27N5O5

Molgewicht417.46

MOL-Datei189188-57-6.mol

Tegaserod maleate physikalisch-chemischer Eigenschaften

Schmelzpunkt	180-183°C
storage temp.	2-8°C
Löslichkeit	Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Sparingly)
Aggregatzustand	powder
Farbe	white to beige
CAS Datenbank	189188-57-6(CAS DataBase Reference)

Gefahreninformationscode (GHS)

Tegaserod maleate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Tegaserod maleate was launched as a new oral treatment of constipationpredominant or diarrhea-predominant irritable bowel syndrome. It can be prepared by condensation of the 5-methoxy-3-formylindole with the appropriate aminoguanidine. Tegaserod is a selective partial agonist of the excitatory 5-HT₄ receptor (K₁ = 18 nM in human caudate membranes) and was designed from the endogenous full agonist, seretonin. In the model of potentiation of the electrically stimulated contraction of longitudinal muscle of guinea pig ileum, Tegaserod exhibited a low-efficacy agonistic activity compared with serotonin. However, it appeared more potent in several studies on intestinal mucosal tissue from various species including man. A lack of effect on the QTc interval was shown in rabbits then confirmed during clinical studies. Tegaserod is also clinically developed for the treatment of other functional GI disorders such as functional dyspepsia and gastroesophageal reflux disease (GERD).
Chemische Eigenschaften
White Powder
Originator
Novartis (Switzerland)
Verwenden
Tegaserod is a gastroproeinetic used in the treatment of irritable bowel syndrome. A selective serotonin 5HT4-receptor partial agonist.
Verwenden
Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.
Trademarks
Zelnorm (Novartis);Zelmac.
Biochem/physiol Actions
It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.
Lager
+4°C

Tegaserod maleate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

189188-57-6, Tegaserod maleate Verwandte Suche:

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