Tegaserod Struktur

Tegaserod

Bezeichnung:Tegaserod

Englisch Name:Tegaserod

CBNumberCB0225423

SummenformelC16H23N5O

Molgewicht301.39

Tegaserod physikalisch-chemischer Eigenschaften

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	20/21/22-36/37/38
S-Sätze:	36/37-36-26

Tegaserod Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Verwenden
Treatment of gastrointestinal motility disorders (selective serotonin 5HT4antagonist).
Definition
ChEBI: Tegaserod is a member of guanidines, a carboxamidine, a member of hydrazines and a member of indoles. It has a role as a serotonergic agonist and a gastrointestinal drug.
Indications
Tegaserod (Zelnorm) is serotonin-4 (5-HT4) receptor agonists that stimulate GI motility.
Trademarks
Zelmac (Novartis).
Clinical Use
Tegaserod is being developed as a treatment for constipation- predominant irritable bowel syndrome (IBS). Within the first week, patients treated with tegaserod had significant improvements in abdominal pain and discomfort, constipation, and overall well-being. Efficacy was maintained throughout the treatment period. Tegaserod also demonstrated significant improvements in the three bowel-related assessments (stool frequency, stool consistency, and straining) within the first week, and these improvements were sustained throughout the treatment period. The most common adverse events reported thus far are headache and diarrhea.