Methylenblau (C.I. 52015)

Bezeichnung:Methylenblau (C.I. 52015)

CAS-Nr61-73-4

Englisch Name:Methylene Blue

CBNumberCB2748858

SummenformelC16H18ClN3S

Molgewicht319.85

MOL-Datei61-73-4.mol

Synonyma

Methylthioniniumchlorid

Methylenblau (C.I. 52015)

Methylenblau (C.I. 52015) physikalisch-chemischer Eigenschaften

Schmelzpunkt	190 °C (dec.)(lit.)
Dichte	1.0 g/mL at 20 °C
Brechungsindex	n20/D1.347
Flammpunkt	45 °C
storage temp.	room temp
Löslichkeit	Soluble in water, ethanol, ethylene glycol, methyl cellosolve
Aggregatzustand	Liquid
pka	2.6, 11.2(at 25℃)
Colour Index	52015
Farbe	Green
Wichte	0.98
Geruch (Odor)	Odorless
Wasserlöslichkeit	40 g/L (20 ºC)
maximale Wellenlänge (λmax)	661 nm
Merck	14,6060
BRN	3641570
Biologische Anwendungen	Detecting microorganisms; treating diabetic retinopathy,macular degeneration,malignant uveal melanomas,erysipelas,hidradenitis suppurativa,inflammation,skin diseases
NIST chemische Informationen	Methylene blue(61-73-4)
EPA chemische Informationen	Methylene blue (61-73-4)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	10-41-22-20/21/22-36/37/38
S-Sätze:	26-39-36
RIDADR	UN 1993 3/PG 3
WGK Germany	3
RTECS-Nr.	SP5740000
HS Code	32049010
Giftige Stoffe Daten	61-73-4(Hazardous Substances Data)
Toxizität	LD50 oral in rat: 1180mg/kg

Gefahreninformationscode (GHS)

Methylene Blue Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R10:Entzündlich.
R41:Gefahr ernster Augenschäden.
R22:Gesundheitsschädlich beim Verschlucken.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Methylene blue is a heterocyclic aromatic chemical compound with the molecular formula C16H18N3SCl. It has many uses in a range of different fields, such as biology and chemistry. At room temperature it appears as a solid, odorless, dark green powder, that yields a blue solution when dissolved in water. The hydrated form has 3 molecules of water per molecule of methylene blue. Methylene blue should not be confused with methyl blue, another histology stain, new methylene blue, nor with the methyl violets often used as pH indicators.
Verwenden
Methylene Blue, 1% w/v aqueous solution is used as a dye in different staining procedures viz. Wright's stain and Jenner's stain. It also serves as an indicator and medicine. Further, it is used to examine RNA and DNA under the microscope or in a gel. It is widely used as a redox indicator in analytical chemistry. It is also used in the sulfide analysis.
Verwenden
A useful inhibitor of cGMP-mediated processes and a useful stain
Definition
ChEBI: An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.
synthetische
MethyleneBlue45,C.I. 52 015 [61-73-4], is obtained by oxidation of 4-aminodimethylaniline in the presence ofsodium thiosulfate to give the quinonediiminothiosulfonic acid, reaction with dimethylaniline, oxidation to the indamine, and cyclization to give the thiazine.
Allgemeine Beschreibung
Methylene blue, also known as methylthioninium chloride, is a photoactive phenothiazine dye. It is a small molecular weight dye, which is effective against Gram positive and Gram negative bacteria.
Hazard
Toxic by ingestion.
Biologische Aktivität
Biological stain and redox indicator. Inhibits tau filament formation (IC 50 = 1.9 μ M). Also inhibits soluble guanylyl cyclase.
Biochem/physiol Actions
Methylene blue (MB) is a highly recognized histological dye. It plays a vital role in microbiology and pharmacology. It has been employed in staining living organisms and in methemoglobinemia treatment. MB exhibits maximum absorption at 664nm. Exposure to methylene blue leads to various health hazards such as increased heart rate, vomiting, shock, Heinz body formation, cyanosis, jaundice, quadriplegia and tissue necrosis in humans
Clinical Use
Methylene blue is 3,7-bis(dimethylamino)-phenazathioniumchloride (Urised). The compound occurs as a dark greencrystalline powder with a metallic appearance that is solublein water (1:25) and alcohol (1:65).
Methylene blue has weak antiseptic properties that makeit useful for the treatment of cystitis and urethritis. The actionof methylene blue is considered to be bacteriostatic.The compound colors the urine and stool blue green.
Sicherheitsprofil
Poison by ingestion,intraperitoneal, intravenous, and subcutaneous routes.Human systemic effects: cyanosis, blood changes.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits verytoxic fumes of NOx, SOx, and
Veterinary Drugs and Treatments
Methylene blue is used primarily for treating methemoglobinemia secondary to oxidative agents (nitrates, chlorates) in ruminants. It is also employed occasionally as adjunctive or alternative therapy for cyanide toxicity.
Intra-operative methylene blue is also being used to preferentially stain islet-cell tumors of the pancreas in dogs in order to aid in their surgical removal or in determining the animal’s prognosis.
läuterung methode
Crystallise the chloride from 0.1M 664 2HCl (16mL/g), the crystals are separated by centrifugation, washed with chilled EtOH and diethyl ether, and dried under vacuum. Crystallise it from 50% aqueous EtOH, wash it with absolute EtOH, and dry it at 50-55o for 24hours. It has also been crystallised from *benzene/MeOH (3:1). It has been salted out with NaCl from a commercial concentrated aqueous solution, then crystallised from water, and dried at 100o in an oven for 8-10hours. [Beilstein 27 III/IV 5152.]

Methylene Blue Upstream-Materialien And Downstream Produkte

Methylenblau (C.I. 52015) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

61-73-4, Methylene Blue Verwandte Suche:

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