Azelainsure Produkt Beschreibung

Azelaic acid Struktur
123-99-9
  • CAS-Nr.123-99-9
  • Bezeichnung:Azelainsure
  • Englisch Name:Azelaic acid
  • Synonyma:Azelainsure
    azelaic;Skinoren;ZK-62498;emerox1110;emerox1144;Emerox 1110;Emerox 1144;Azelainsure;Azeloic acid;Anchoec acid
  • CBNumber:CB6852982
  • Summenformel:C9H16O4
  • Molgewicht:188.22
  • MOL-Datei:123-99-9.mol
Azelainsure physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :98 °C
  • Siedepunkt: :286 °C100 mm Hg(lit.)
  • Dichte :1,029 g/cm3
  • Dampfdichte :6.5 (vs air)
  • Dampfdruck :<1 mm Hg ( 20 °C)
  • Brechungsindex :1.4303
  • Flammpunkt: :215 °C
  • storage temp.  :2-8°C
  • Löslichkeit :2.4g/l
  • pka :4.53, 5.33(at 25℃)
  • Aggregatzustand :Slightly Crystalline Powder or Flakes
  • Farbe :White to slightly yellow
  • PH :3.5 (1g/l, H2O)
  • Wasserlöslichkeit :2.4 g/L (20 ºC)
  • Merck  :14,905
  • BRN  :1101094
  • Stabilität: :Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days.
  • InChIKey :BDJRBEYXGGNYIS-UHFFFAOYSA-N
  • CAS Datenbank :123-99-9(CAS DataBase Reference)
  • NIST chemische Informationen :Nonanedioic acid(123-99-9)
  • EPA chemische Informationen :Azelaic acid (123-99-9)
Sicherheit

Azelaic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S24/25:Berührung mit den Augen und der Haut vermeiden.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  • Beschreibung Azelaic acid is a topical antiacne agent which exerts its therapeutic action through a myriad of antimicrobial, antiproliferative and cytostatic effects. In vitro, azelaic acid hasbeen shown to inhibit DNA polymerases in several tumor cell lines.
  • Chemische Eigenschaften white to cream solid
  • Chemische Eigenschaften Azelaic acid is an organic compound with the formula (CH2)7(CO2H)2. This saturated dicarboxylic acid exists as a white powder. It is found in wheat, rye, and barley. It is a component of a number of hair and skin conditioners.
  • Chemische Eigenschaften Nonanedioic acid is the best known dicarboxylic acid. Its name stems from the action of nitric acid (azote, nitrogen, or azotic, nitric) oxidation of oleic or elaidic acid. It was detected among products of rancid fats. Its origin explains for its presence in poorly preserved samples of linseed oil and in specimens of ointment removed from Egyptian tombs 5000 years old. Azelaic acid was prepared by oxidation of oleic acid with potassium permanganate, but now by oxidative cleavage of oleic acid with chromic acid or by ozonolysis. Azelaic acid is used, as simple esters or branched-chain esters) in the manufacture of plasticizers (for vinyl chloride resins, rubber), lubricants and greases. Azelaic acid is now used in cosmetics (treatment of acne). It displays bacteriostatic and bactericidal properties against a variety of aerobic and anaerobic micro-organisms present on acne-bearing skin. Azelaic acid was identified as a molecule that accumulated at elevated levels in some parts of plants and was shown to be able to enhance the resistance of plants to infections.
  • Originator Schering AG (W. Germany)
  • Verwenden antiacne, antiproliferative agent
  • Verwenden antifungal, binds to membrane sterols
  • Verwenden Azelaic acid is used in lacquers, alkyd resins, plasticizers, adhesives, polyamides, urethane elastomers, and organic syntheses. Azelaic acid is also used in treating of acne.
  • Indications Azelaic acid (Azelex) is a naturally occurring dicarboxylic acid produced by the yeast Malassezia furfur. Azelaic acid inhibits tyrosinase, a rate-limiting enzyme in the synthesis of the pigment melanin. This may explain why diminution of melanin pigmentation occurs in the skin of some patients with pityriasis versicolor, a disease caused by M. furfur. Azelaic acid is bacteriostatic against a number of species thought to participate in the pathogenesis of acne, including Propionibacterium acnes. The drug may also reduce microcomedo formation by promoting normalization of epidermal keratinocytes.
  • Application Polymers and related materials
    Esters of this dicarboxylic acid find applications in lubrication and plasticizers. With hexamethylenediamine azelaic acid forms Nylon - 6,9, which finds specialized uses as a plastic.
    Medical
    Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne . It belongs to a class of medication called dicarboxylic acids. It works by killing acne bacteria that infect skin pores. It also decreases the production of keratin, which is a natural substance that promotes the growth of acne bacteria Azelaic acid is also used as a topical gel treatment for rosacea, due to its ability to reduce inflammation . It clears the bumps and swelling caused by Rosacea. Azelaic acid has been used for treatment of skin pigmentation including melasma and post inflammatory hyper pigmentation , particularly in those with darker skin types. It has been recommended as an alternative to hydroquinone (HQ). As a tyrosinase inhibitor, azelaic acid reduces synthesis of melanin.
    Brand names
    AzClear Action ( 20 % lotion, Ego Pharmaceuticals), Azelex (20% cream, Allergan), White Action cream (20 % cream ,2 % glycolic acid), SynCare), Finacea (15 % gel, Intendis/Berlex Laboratories, subsidiaries of Bayer AG), Finevin (20 % cream, Intendis / Berlex Laboratories), Skinoren (20 % cream or 15% gel, Intendis), Melazepam, Strata Dermatologics, 2oz, Mixed Dicarboxylic Acids 20 % Azelaic Acid Cream.,and Azaclear (azelaic acid and niacinamide, Epikinetics LLC). .
  • Vorbereitung Methode Azelaic acid is industrially produced by the ozonolysis of oleic acid. The side product is nonanoic acid. It is produced naturally by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. The bacterial degradation of nonanoic acid gives azelaic acid.
  • Trademarks Azelex (Allergan); Finacea (Intendis);Skinoren.
  • Biotechnological Applications In plants, azelaic acid serves as a "distress flare" involved in defense responses after infection. It serves as a signal that induces the accumulation of salicylic acid, an important component of a plant's defensive response.
  • Clinical Use Azelaic acid is used for the treatment of mild to moderate acne, particularly in cases characterized by marked inflammation-associated hyperpigmentation.
  • läuterung methode Recrystallise it from H2O(charcoal) or thiophene-free *benzene. The acid can be dried by azeotropic distillation with toluene, the residual toluene solution is then cooled and filtered, and the precipitate is dried in a vacuum oven. It has been purified by zone refining or by sublimation onto a cold finger at 10-3torr. It distils above 360o with partial formation of the anhydride. The dimethyl ester has m –3.9o and b 140o/8mm. [Hill & McEwen Org Synth Coll Vol II 53 1943, Beilstein 2 IV 2055.]
Azelaic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Azelainsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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123-99-9, Azelaic acid Verwandte Suche:
  • Water-soluble azelaic acid
  • 1,7-Dicarboxyheptane
  • azelaic
  • Azelaic acid, technical grade
  • Azelaic acid, tech., flakes
  • Nonanedioic acid 1,7-Heptanedicarboxylic Acid
  • Azeloic acid
  • Azelaic acid( Micronized )
  • Azelaic acid, 98% 25GR
  • Azelaic Acid 98%
  • 1,7-Heptanedicarboxylic Acid Nonanedioic Acid
  • Azelaic acid(Nonanedioic acid)
  • Azelaic Acid,1,7-Heptanedicarboxylic Acid
  • 1.7-Heptanedic
  • Azelaic acid technical, ~85% (GC)
  • Azelaic acid Vetec(TM) reagent grade
  • Azelaic acid5x100g
  • Anchoic acid,Lepargylic acid
  • Azelaic acid≥ 99% (Assay)
  • Azelaic acid Manufacturer
  • azelaicacid,technicalgrade
  • Azelainic acid
  • Emerox 1110
  • Emerox 1144
  • emerox1110
  • emerox1144
  • Emery's L-110
  • ninandioic acid
  • AZELAIC ACID TECH. 85-90% FLAKES
  • AZELAIC ACID 98+%
  • Anchoec acid
  • AZELAIC ACID, ULTRAPURE
  • Azelaic acid, tech., flakes, 85-90%
  • nonanedionic acid
  • Azelainsure
  • nonadioic acid
  • AZELAIC ACID [1,7-HEPATANEDICARBOXYLIC ACID]
  • Azelaic acid, 95+%
  • 1,7-HEPTANEDICARBOXYLIC
  • Azelaic acid, 85-90%, tech., flakes
  • Heptanedicarboxylic acid
  • heptanedicarboxylicacid
  • n-Nonanedioic acid
  • Skinoren
  • ZK-62498
  • ANCHOIC ACID
  • 1,9-NONANEDIOIC ACID
  • 1,7-HEPTANEDICARBOXYLIC ACID
  • LEPARGYLIC ACID
  • AZELAIC ACID
  • DICARBOXYLIC ACID C9
  • NONANEDIOC ACID
  • NONANEDIOIC ACID
  • N-HEPTANE-1,7-DICARBOXYLIC ACID
  • RARECHEM AL BO 0186
  • Azalaic Acid
  • Azelaicacidtech
  • Nanoactive Aze