Sulfachlorpyridazin

Bezeichnung:Sulfachlorpyridazin

CAS-Nr80-32-0

Englisch Name:SULFACHLOROPYRIDAZINE

CBNumberCB6724544

SummenformelC10H9ClN4O2S

Molgewicht284.72

MOL-Datei80-32-0.mol

Synonyma

Sulfachlorpyridazin

Sulfachlorpyridazin physikalisch-chemischer Eigenschaften

Schmelzpunkt	186-187℃
Siedepunkt	559.7±60.0 °C(Predicted)
Dichte	1.588
Brechungsindex	1.6300 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	0.5 M NaOH: soluble50mg/mL
pka	pKa 6.10 (Uncertain)
Aggregatzustand	powder
Farbe	off-white to light yellow
BRN	261558
EPA chemische Informationen	Benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)- (80-32-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	43
S-Sätze:	36/37
WGK Germany	3
HazardClass	IRRITANT
HS Code	2935909550

Gefahreninformationscode (GHS)

SULFACHLOROPYRIDAZINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Originator
Sonilyn,Mallinckrodt Inc.,US,1962
Verwenden
Sulfachloropyridazine is an antibacterial compound.This compound is a contaminant of emerging concern (CECs).
Definition
ChEBI: A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.
Manufacturing Process
1.9 parts of 3,6-dichloropyridazine, 3.4 parts of sulfanilamide, 2.7 parts of potassium carbonate and 1 part of sodium chloride were ground together. The solid mixture was heated with stirring and as the dichloropyridazine and sulfanilamide melted, the mixture became a slurry. When the bath temperature had reached 140°C a sudden evolution of carbon dioxide occurred which lasted about 5 minutes, after which the mixture set in fine granules. When no more carbon dioxide was evolved, heating was stopped and the reaction mixture was heated with sufficient water to dissolve it and the solution allowed to cool. Unreacted sulfanilamide was collected by filtration. Excess dichloropyridazine was removed from the filtrate by extraction with a water immiscible organic solvent such as ether.
The basic solution was chilled and poured into one-half volume of 1:3 acetic acid. Sufficient hydrochloric acid was added to bring the mixture to pH 4. The crude 3-sulfanilamido-6-chloropyridazine which precipitated was purified by solution in 6 parts of 1:100 ammonium hydroxide, charcoal treatment and precipitation by pouring of the filtrate into dilute acetic acid.
Trademarks
Nefrosul (3M Pharmaceuticals); Sonilyn,(Carter-Wallace); Vetisulid [Veterinary] (Fort Dodge Animal Health).
Therapeutic Function
Antibacterial

SULFACHLOROPYRIDAZINE Upstream-Materialien And Downstream Produkte

Sulfachlorpyridazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

80-32-0, SULFACHLOROPYRIDAZINE Verwandte Suche:

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