Phenylquecksilberacetat

Bezeichnung:Phenylquecksilberacetat

CAS-Nr62-38-4

Englisch Name:PHENYLMERCURIC ACETATE

CBNumberCB6703824

SummenformelC8H8HgO2

Molgewicht336.74

MOL-Datei62-38-4.mol

Synonyma

Phenylquecksilberacetat

Phenylquecksilber(II)-acetat

Phenylmercuriacetat

Phenylquecksilberacetat physikalisch-chemischer Eigenschaften

Schmelzpunkt	148-151 °C(lit.)
Dichte	2,4 g/cm³
storage temp.	APPROX 4°C
Löslichkeit	Slightly soluble in water, soluble in acetone and in alcohol.
Aggregatzustand	Powder
Wichte	2.4
Farbe	white
Geruch (Odor)	Acetic acid odor
Wasserlöslichkeit	Soluble in alcohol, benzene and glacial acetic acid. Slightly soluble in water.
Merck	14,7300
Stabilität	Stable. Incompatible with strong oxidizing agents.
CAS Datenbank	62-38-4(CAS DataBase Reference)
EPA chemische Informationen	Phenylmercury acetate (62-38-4)

Sicherheit

Kennzeichnung gefährlicher	T,N
R-Sätze:	25-34-48/24/25-50/53
S-Sätze:	23-24/25-37-45-60-61
RIDADR	UN 1674 6.1/PG 2
WGK Germany	3
RTECS-Nr.	OV6475000
F	8
TSCA	Yes
HazardClass	6.1
PackingGroup	II
HS Code	28521000
Giftige Stoffe Daten	62-38-4(Hazardous Substances Data)
Toxizität	LD50 oral in rat: 41mg/kg

Gefahreninformationscode (GHS)

PHENYLMERCURIC ACETATE Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
GERUCHLOSES, HYGROSKOPISCHES, WEISSES ODER GELBWEISSES, KRISTALLINES PULVER.
PHYSIKALISCHE GEFAHREN
Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger Quecksilber- und Quecksilberoxiddämpfe. Reagiert mit starken Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV: (als Hg) 0,1 mg/m?(als TWA); Hautresorption; (ACGIH 2005).
MAK: (Quecksilberverbindungen, organisch) Hautresorption; Sensibilisierung der Haut; Krebserzeugend Kategorie 3B; (DFG 2006).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut, und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Versprühen schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz verätzt die Augen, die Haut und die Atemwege. ätzend beim Verschlucken. Möglich sind Auswirkungen auf die Nieren mit nachfolgendem Nierenversagen. Die Auswirkungen treten u.U. verzögert ein. (s. Anm.) ärztliche Beobachtung notwendig.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen. Möglich sind Auswirkungen auf das Nervensystemund die Nieren mit nachfolgender nervöser Störung und Nierenschäden.
LECKAGE
Zündquellen entfernen. Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. An sicheren Ort bringen. Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R34:Verursacht Verätzungen.
R48/24/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Berührung mit der Haut und durch Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37:Geeignete Schutzhandschuhe tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Chemische Eigenschaften
white crystalline powder
Chemische Eigenschaften
Phenylmercuric acetate occurs as a white to creamy white, odorless or almost odorless, crystalline powder or as small white prisms or leaflets.
Chemische Eigenschaften
Phenylmercury acetate is a white or yellow crystalline solid.
Verwenden
Herbicide; fungicide.
Verwenden
antiulcer
Verwenden
Phenylmercuric acetate is used as catalyst; fungicide; herbicide; algicide; preservative in antibiotic eye drops, eye cosmetics, shampoos, etc.
Vorbereitung Methode
Phenylmercuric acetate is readily formed by heating benzene with mercuric acetate.
Definition
ChEBI: Phenylmercury acetate is an arylmercury compound and a member of benzenes.
Allgemeine Beschreibung
Small lustrous prisms. Toxic by ingestion, inhalation and skin absorption. May severely irritate skin and eyes. Used as an herbicide and fungicide. as such, is mixed with organic solvent for the purpose of application.
Reaktivität anzeigen
PHENYLMERCURIC ACETATE may react with strong oxidizing agents .
Health Hazard
Extremely toxic. The probable oral lethal dose for humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful for a 70 kg (150 lb.) person.
Brandgefahr
Fire may produce irritating or poisonous gases. When heated to decomposition, very toxic mercuric fumes may be given off. Phenylmercuric ion is incompatible with halides, with which precipitates are formed.
Pharmazeutische Anwendungen
Phenylmercuric acetate is used as an alternative antimicrobial preservative to phenylmercuric borate or phenylmercuric nitrate in a limited range of cosmetics (in concentrations not exceeding 0.007% of mercury calculated as the metal) and pharmaceuticals. It may be used in preference to phenylmercuric nitrate owing to its greater solubility.
Phenylmercuric acetate is also used as a spermicide;
Sicherheitsprofil
Poison by ingestion, intravenous, intraperitoneal, subcutaneous, and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also MERCURY COMPOUNDS. When heated to decomposition it emits toxic fumes of Hg.
Sicherheit(Safety)
Phenylmercuric acetate is mainly used as an antimicrobial preservative in topical pharmaceutical formulations. A number of adverse reactions to mercury-containing preservatives have been reported; see Phenylmercuric Nitrate.
LD₅₀ (chicken, oral): 60 mg/kg
LD₅₀ (mouse, IP): 13 mg/kg
LD₅₀ (mouse, IV): 18 mg/kg
LD₅₀ (mouse, oral): 13 mg/kg
LD₅₀ (mouse, SC): 12 mg/kg
LD₅₀ (rat, oral): 41 mg/kg
mögliche Exposition
Phenylmercury acetate is used as an antiseptic, fungicide; for fungal and bacterial control; herbicide and control of crabgrass; mildewcide for paints; slimicide in paper mills. It was also used in contraceptive gels and foams.
Environmental Fate
If released into air, soil, or water, phenylmercuric acetate is unlikely to volatilize and is instead expected to be bound to particulates based on a low vapor pressure (6 × 10^-6 mm Hg) and low Henry’s constant (5.66 × 10^-10 atmm3 mol ^-1). Photolysis has the potential to degrade phenylmercuric acetate, releasing inorganic mercury which can volatilize and enter the atmosphere from superficial soils or water. If released into soil, the mobility of parent phenylmercuric acetic acid is expected to be high based on a Koc of 60. Water releases would result in quick dispersion since water solubility is high (4370 mg l^-1). Once in solution, especially with harder water, it will dissociate into a salt. The cation will adsorb to particulates or humics suspended in the water column or in sediment, with little bioconcentration in aquatic species.
Lager
As for other phenylmercuric salts; see Phenylmercuric Nitrate.
Phenylmercuric acetate should be stored in a well-closed container, protected from light, in a cool, dry place.
Versand/Shipping
UN1674 Phenylmercuric acetate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
läuterung methode
It forms small colourless lustrous prisms from EtOH. Its solubility in H2O is 0.17%, but it is more soluble in EtOH, Me2CO and *C6H6. [Maynard J Am Chem Soc 46 1510 1925, Coleman et al. J Am Chem Soc 59 2703 1937, J Am Pharm Assoc 25 752 1936, Beilstein 16 IV 1720.] See PhHgOH below.
Toxicity evaluation
Toxic effects of phenylmercuric acetate are correlated with its rapid metabolic breakdown into the mercuric ion. Generally, mercury interferes with cellular enzymatic mechanisms by combining with sulfhydryl (–SH) groups of different enzymes and thereby produces nonspecific cell injury or death.
Inkompatibilitäten
A strong reducing agent. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, halogens.
Inkompatibilitäten
As for other phenylmercuric salts; see Phenylmercuric Nitrate.
Incompatible with: halides; anionic emulsifying agents and suspending agents; tragacanth; starch; talc; sodium metabisulfite; sodium thiosulfate; disodium edetate; silicates; aluminum and other metals; amino acids; ammonia and ammonium salts; sulfur compounds; rubber; and some plastics.
Phenylmercuric acetate is reported to be incompatible with cefuroxime and ceftazidime.
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. React to produce soluble nitrate form, precipitate as mercuric sulfide. Return to supplier.
Regulatory Status
Included in the FDA Inactive Ingredients Database (ophthalmic ointments; topical emulsions/creams; vaginal emulsions/creams). Included in the Canadian List of Acceptable Non-medicinal Ingredients (ophthalmic, nasal and otic preparations up to 0.004%; there must be no other suitable alternative preservative available).
Phenylmercuric acetate is no longer permitted to be used as a pesticide in the USA. Its use in cosmetic products in the USA is limited to eye area cosmetics at not more than 0.0065% provided that there is no other suitable available preservative. It is specifically prohibited in vaginal contraceptive drug products and antimicrobial diaper rash drug products in the USA. Phenylmercuric compounds are prohibited from use in cosmetic products in Canada.
In Europe, use in cosmetic products is limited to eye makeup and eye makeup remover at concentrations not exceeding 0.007% mercury alone or in combination with other permitted mercurial compounds.In France, a maximum concentration of 0.01% is permitted for use in pharmaceuticals. The use of mercurial compounds in cosmetics in Japan is limited to concentrated shampoo or cream at not more than 0.003% Hg and eye makeup at not more than 0.0065% Hg.

PHENYLMERCURIC ACETATE Upstream-Materialien And Downstream Produkte

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