Bis(1-hydroxy-2(1H)-pyridinthiona-to-O,S)zink

Bezeichnung:Bis(1-hydroxy-2(1H)-pyridinthiona-to-O,S)zink

CAS-Nr13463-41-7

Englisch Name:Zinc pyrithione

CBNumberCB6456070

SummenformelC10H8N2O2S2Zn

Molgewicht317.7

MOL-Datei13463-41-7.mol

Synonyma

Pyrithionzink

Bis(1-hydroxy-2(1H)-pyridinthiona-to-O,S)zink

Bis(1-hydroxy-2(1H)-pyridinthiona-to-O,S)zink physikalisch-chemischer Eigenschaften

Schmelzpunkt	approximate 240℃
Dichte	1.782 g/cm3(Temp: 25 °C)
Dampfdruck	0Pa at 25℃
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	almost transparency in Pyridine
Aggregatzustand	Powder
Farbe	White to Orange to Green
Geruch (Odor)	Mild Characteristic
Wasserlöslichkeit	Insoluble (<0.1 g/100 mL at 21 ºC)
Merck	14,7994
InChI	InChI=1S/2C5H5NOS.Zn/c27-6-4-2-1-3-5(6)8;/h21-4,8H;/q;;+2/p-2
InChIKey	OTPSWLRZXRHDNX-UHFFFAOYSA-L
SMILES	C1(C=CC=C[N+]=1[O-])S[Zn]SC1C=CC=C[N+]=1[O-]
LogP	0.9 at 25℃ and pH7.5-7.7
Oberflächenspannung	73mN/m at 7.22mg/L and 20℃
CAS Datenbank	13463-41-7(CAS DataBase Reference)
EPA chemische Informationen	Zinc pyrithione (13463-41-7)

Sicherheit

Kennzeichnung gefährlicher	T+,N,T
R-Sätze:	24/25-26-37/38-41-50/53-23-22
S-Sätze:	26-28-36/37/39-45-61-60-39
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	ZH0950000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29333990
Giftige Stoffe Daten	13463-41-7(Hazardous Substances Data)
Toxizität	LD50 oral in rat: 177mg/kg

Gefahreninformationscode (GHS)

Zinc pyrithione Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augenschäden.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 μg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff.
Chemische Eigenschaften
Beige granules
Verwenden
Reactions may lead to photosensitive eczema and actinic reticuloid syndrome. Zinc pyrithione is used as antifungal, antibacterial and antiseborrheic agent used in many shampoos and hair creams.
Verwenden
zinc pyrithione is a preservative against bacteria, fungi, and yeast. It is unstable in light and in the presence of oxidizing agents. Zinc pyrithione is useful in gels, creams, heavy lotions, and talcum powder.
Verwenden
Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks.

Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.
Indications
Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.
Trademarks
Head & Shoulders Conditioner (Procter & Gamble).
Allgemeine Beschreibung
Fine beige granules.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Organometallics, such as Zinc pyrithione, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases.
Brandgefahr
Flash point data for Zinc pyrithione are not available, but Zinc pyrithione is probably combustible.
Kontakt-Allergie
Zinc pyrithione is widely used in antidandruff shampoos and is a classic allergen. Concomitant reactions are expected to both zinc and sodium pyrithione.
Sicherheitsprofil
Poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx, SOx, and ZnO. Used as an anti- dandruff agent in shampoos. See also ZINC COMPOUNDS and SULFIDES.
Synthese
1000 g of sodium pyrithione, 20% aqueous solution (1.34 mmol of sodium pyrithione) was added to a 2L reactor equipped with a mechanical agitator and warmed to 70 °C with stirring. To the solution was added 190 g of 50 % zinc chloride (0.7 mmol of zinc chloride) over 10 minutes. After the completion of the addition, the solution was stirred at 70 °C for one hour, dehydrated and then washed with 500 g of distilled water. The solid thus obtained was dried with a heated-air drier at 70 °C to have a moisture content of less than 0.5 % and ground with a hammer mill to obtain a find powder of zinc pyrithione. The zinc pyrithione thus obtained was 212 g with a yield of 99.5 %.

Zinc pyrithione Upstream-Materialien And Downstream Produkte

Bis(1-hydroxy-2(1H)-pyridinthiona-to-O,S)zink Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

13463-41-7, Zinc pyrithione Verwandte Suche:

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