Pyridin-4-ol

Bezeichnung:Pyridin-4-ol

CAS-Nr626-64-2

Englisch Name:4-Hydroxypyridine

CBNumberCB6303828

SummenformelC5H5NO

Molgewicht95.1

MOL-Datei626-64-2.mol

Synonyma

Pyridin-4-ol

Pyridin-4-ol physikalisch-chemischer Eigenschaften

Schmelzpunkt	150-151 °C (lit.)
Siedepunkt	230-235 °C/12 mmHg (lit.)
Dichte	1.1418 (rough estimate)
Brechungsindex	1.5939 (estimate)
Flammpunkt	221 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Powder or Chunks
pka	3.2(at 20℃)
Farbe	Beige to light brown
Wasserlöslichkeit	Soluble
BRN	105800
InChIKey	GCNTZFIIOFTKIY-UHFFFAOYSA-N
LogP	-1.300 (est)
CAS Datenbank	626-64-2(CAS DataBase Reference)
NIST chemische Informationen	4-Pyridinol(626-64-2)
EPA chemische Informationen	4-Pyridinol (626-64-2)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-41-37/38-22
S-Sätze:	26-36-37/39-39
WGK Germany	3
RTECS-Nr.	UU7701450
F	3-8-10
Hazard Note	Harmful/Irritant
TSCA	Yes
HazardClass	IRRITANT
HS Code	29339900

Gefahreninformationscode (GHS)

4-Hydroxypyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
4-Hydroxypyridine, available from pyridylpyridinium chloride hydrochloride, is the substrate for diodone and its n-propyl ester, propyliodone. 4-Hydroxypyridine (4-HP) is a non-nucleophilic analog of the product phenol found to bind specifically to and stabilize the aminoacrylate intermediate. When 4-HP is added to Tyrosine phenol-lyase (TPL) reactions, an absorption peak at 340 nm is observed. The formation of the 340 nm peak correlates with the decay of the quinonoid intermediate peak at 505 nm, with a clean isosbestic point, and the observed rate constants show an inverse dependence on the concentration of 4-HP. These results confirm that the observed peak at 340 nm is due to the formation of the amino acrylate intermediate[1-2].
Chemische Eigenschaften
Beige crystalline powder
Verwenden
4-Hydroxypyridine was used in the synthesis of (Ag₃MoO₃F₃) (Ag₃MoO₄)Cl by hydro(solvato)thermal methods. It was used as model compound to study the natural photodegradation of representative aquatic environmental contaminants.
Definition
ChEBI: A monohydroxypyridine that is pyridine in which the hydrogen at position 4 has been replaced by a hydroxy group.
läuterung methode
Crystallise 4-pyridone from H2O or wet CHCl3 as the monohydrate. It loses H2O on drying in vacuo over H2SO4. Store it over KOH because it is hygroscopic.[Beilstein 21 III/IV 446, 21/7 V 152.]
Einzelnachweise
[1] Yates, F. S. “2.09 – Pyridines and their Benzo Derivatives: (vi) Applications.”Comprehensive Heterocyclic Chemistry 2 (1984): 511-524.
[1] Robert S Phillips, Olivia Bauer. “Characterization of aminoacrylate intermediates of pyridoxal-5’-phosphate dependent enzymes.” Methods in enzymology 685 (2023): 199–224.

4-Hydroxypyridine Upstream-Materialien And Downstream Produkte

Pyridin-4-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

626-64-2, 4-Hydroxypyridine Verwandte Suche:

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