Buserelin

Bezeichnung:Buserelin

Englisch Name:BUSERELIN

CBNumberCB6287694

SummenformelC60H86N16O13

Molgewicht1239.42

Synonyma

Buserelin

Buserelin physikalisch-chemischer Eigenschaften

alpha	D20 -40.4° (c = 1 in dimethylacetamide)
Siedepunkt	845.19°C (rough estimate)
Dichte	1.0711 (rough estimate)
Brechungsindex	1.6200 (estimate)
Löslichkeit	Sparingly soluble in water and in dilute acids.
pka	9.82±0.15(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Stabilität	Hygroscopic
InChIKey	CUWODFFVMXJOKD-UHFFFAOYSA-N

Sicherheit

HS Code

2937190000

Gefahreninformationscode (GHS)

Beschreibung
Buserelin (Suprefact?) is a hormonal therapy drug used to treat advanced prostate cancer. It is a medication which is used primarily in the treatment of prostate cancer and endometriosis. It is also used for other indications such as the treatment of premenopausal breast cancer, uterine fibroids, and early puberty, in assisted reproduction for female infertility, and as a part of transgender hormone therapy. In addition, buserelin is used in veterinary medicine. The medication is typically used as a nasal spray three times per day, but is also available for use as a solution or implant for injection into fat.
Chemische Eigenschaften
White or slightly yellowish powder, hygroscopic.
Verwenden
Gonad-stimulating principle.
Definition
ChEBI: Buserelin is an oligopeptide.
Trademarks
Suprefact (Hoechst-Roussel).
Clinical Use

Treatment of advanced prostate cancer and endometriosis

Pituitary desensitisation in preparation for ovulation induction regimens using gonadotrophins
Nebenwirkungen
Using too much Buserelin Injection may make you feel weak, nervous, dizzy and sick. You may also have a headache, hot flushes, stomach pain, swelling of the legs and breast pain. You may also have pain, bleeding or hardening of the skin at the site of injection
Stoffwechsel
Metabolic inactivation by peptides occurs in the liver and kidney. The drug is also inactivated by pituitary membrane enzymes. Excreted in the urine and bile as unchanged drug and metabolites.