Protirelin

Bezeichnung:Protirelin

CAS-Nr24305-27-9

Englisch Name:Thyrotropin-releasing hormone

CBNumberCB1408948

SummenformelC16H22N6O4

Molgewicht362.38

MOL-Datei24305-27-9.mol

Synonyma

Protirelin

Protirelin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>143°C (dec.)
alpha	-50 (D/25℃) (c=1.5, H2O)-65.5 (D) (c=1.0, H2O)
Siedepunkt	494°C (rough estimate)
Dichte	1.1675 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	−20°C
Löslichkeit	H₂O: 10 mg/mL, clear, colorless
pka	13.05±0.20(Predicted)
Aggregatzustand	powder
Farbe	White to Off-White
PH	pH (10g/l, 25℃) : 3.0～4.0
Merck	13,9663
BRN	770238
Stabilität	Hygroscopic
InChIKey	ITYONPBTNRIEBA-SRVKXCTJSA-N
CAS Datenbank	24305-27-9

Sicherheit

S-Sätze:	22-24/25
WGK Germany	2
RTECS-Nr.	TW3580000
F	10-21

Gefahreninformationscode (GHS)

Thyrotropin-releasing hormone Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
The first hypothalamic hypophysiotropic neurohormone identified, TRH consists of the tripeptide pGlu-His-ProNH2. It stimulates the secretion ofthyroid-stimulating hormone (TSH), prolactin (PRL), and growth hormone (GH), and also functions as a neurotransmitter and neuromodulator.
Chemische Eigenschaften
White or yellowish-white powder, hygroscopic.
Verwenden
prothyrotropin
Verwenden
Thyrotropin-Releasing Hormone is a hypothalamic hypophysiotropic neuropeptide, which has the ability to stimulate the release of thyroid-stimulating hormone in mammals. It is proven that Thyrotropin-Releasing Hormone can be used to accelerate wound healing.
Indications
Thyrotropin-releasing hormone, or protirelin, consists of three amino acids. TRH (Relefact TRH) is used for tests to distinguish primary from secondary hypothyroidism.
Definition
ChEBI: Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide.
Allgemeine Beschreibung
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract.
Biochem/physiol Actions
Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary. It also plays a vital role as a neurotransmitter and neuromodulator.
Clinical Use
TRH (200–500μg) administered intravenously to normal subjects causes a rise in TSH levels within 15–30min, resulting in an increase in T3 levels within 90–150min. In primary hypothyroidism, TSH hyperresponse to TRH occurs, with a typical elevation in the basal TSH levels. In secondary (pituitary) hypothyroidism, an impaired TSH response to TRH occurs, whereas in tertiary (hypothalamic) hypothyroidism normal or increased TSH response to TRH occurs. Protirelin is used to test the response of the anterior pituitary to TRH in people who may have medical conditions of thyroid function, including hyperthyroidism, Graves’ disease, and hypothyroidism. In addition, TRH has been used to assess the ability of the prolactin secretion in the pituitary.
Nebenwirkungen
The peak TSH response to intravenous TRH occurs at 20 minutes. The mild and transient side effects, which occur only after intravenous TRH, include nausea, a flushing sensation, a desire to micturate, a peculiar taste, and tightness in the chest[1].

Protirelin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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