Ornipressin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Ornipressin Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  POR-8 ,Sandoz,W. Germany ,1977

• Verwenden

  Ornipressin is an analogue of Vasopressin. Ornipressin is used as a vasoconstrictor, haemostatic and renal agent.

• Definition

  ChEBI: Ornipressin is an oligopeptide.

• Manufacturing Process

  (a)N-α-carbobenzoxy-N-δ-p-toluenesulfonyl-L-ornithyl-glycine ethyl ester: 104 g of N-α-carbobenzoxy-N-δ-p-toluenesulfonyl-L-ornithine and 27 g of glycine ethyl ester are dissolved in 450 cc of acetonitrile, the mixture is cooled at 0°C, 51 g of dicyclohexyl carbodiimide are added and the mixture is shaken at room temperature for 4 hours. Precipitated dicyclohexyl urea is filtered off and washed with acetonitrile. The whole filtrate is evaporated in a vacuum. The residue crystallizes after the addition of petroleum ether. After recrystallization from n-propanol, 93 g of N-α-carbobenzoxy-N-δ-toluenesulfonyl-L-ornithylglycine ethyl ester are obtained; melting point 136°C; [α]D22 = -6.5° (96% ethanol).
  (b) N-carbobenzoxy-L-prolyl-N-δ-p-toluenesulfonyl-L-ornithyl-glycinamide: 90 g of N-α-carbobenzoxy-N-δ-p-toluenesulfonyl-L-ornithyl-glycine ethyl ester are dissolved in 800 cc of anhydrous acetic acid which has been saturated with hydrogen bromide. The mixture is left to stand for one hour at 20°C, evaporated in a vacuum at a temperature below 40°C and the residue washed carefully with diethyl ether. The residue is dissolved in 500 cc of acetonitrile, 25 cc of triethylamine and 43 g of N-carbobenzoxy-L-proline are added, cooling is effected at 0°C, 355 g of dicyclohexyl carbodiimide are then added and the mixture shaken overnight at 20°C. After filtering off dicyclohexyl urea, the filtrate is evaporated in a vacuum at 30°C, the residue dissolved in ethyl acetate and this solution is washed with dilute sulfuric acid and aqueous ammonia. After drying over sodium sulfate, the ethyl acetate is removed by evaporation in a vacuum and the residue dissolved in 1 liter of absolute ethanol. The solution is cooled at 0°C, saturated with ammonia and left to stand overnight at 20°C. After evaporating in a vacuum at 30°C, the residue is recrystallized from dimethylformamide/ethyl acetate. 58 g of Ncarbobenzoxy-L-prolyl-N-δ-p-toluenesulfonyl-L-ornithyl-glycinamide are obtained: melting point 122°C (with decomposition).
  (c) N-carbobenzoxy-L-glutaminyl-L-asparaginyl-S-benzyl-L-cystsinyl-L-prolyl-Nδ-p-toluenesulfonyl-L-ornithyl-glycinamide: 100 g of N-carbobenzoxy-L-prolylN-δ-p-toluenesulfonyl-L-ornithyl-glycinamide are dissolved in 500 cc of anhydrous acetic acid which has been saturated with hydrogen bromide, the solution is left to stand for one hour at 20°C and is evaporated in a vacuum at a temperature below 40°C. The residue is carefully washed with diethyl ether and then added to a solution of 100 g of N-carbobenzoxy-L-glutaminyl-Lasparaginyl-S-benzyl-L-cysteinyl-azide and 26 cc of triethylamine in 1,000 cc of dimethylformamide. The mixture is left to stand overnight at 20°C, 3,000 cc of ethyl acetate are added thereto, the precipitate is filtered off and washing is effected with ethyl acetate. 105 g of N-carbo-benzoxy-Lglutaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-L-prolyl-N-δ-p-toluenesulfonyl-Lornithyl-glycinamide are obtained; melting point 193°C; [α]D20 = 38.5°(dimethylformamide).
  (d) N-carbobenzoxy-S-benzyl-L-cysteinyl-L-tyrosyl-L-phenyl-alanyl-Lglutaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-L-prolyl-N-δ-p-toluenesulfonyl-Lornithyl-glycinamide: 50 g N-carbobenzoxy-L-glutaminyl-L-asparaginyl-Sbenzyl-L-cysteinyl-L-prolyl-N-δ-p-toluenesulfonyl-L-ornithyl-glycinamide are dissolved in 250 cc of anhydrous acetic acid which has been saturated with hydrogen bromide and the solution is left to stand for one hour at 20°C. After evaporating the solvent in a vacuum at a temperature below 40°C, the residue is carefully washed with diethyl ether and a solution of 31.5 g of Ncarbobenzoxy-S-benzyl-L-cysteinyl-L-tyrosyl-L-phenylalanine-azide and 7.5 cc of triethylamine in 250 cc of dimethylformamide is added thereto. The mixture is left to stand for 2 days at 20°C. 1,000 cc of ethyl acetate are subsequently added and the precipitate is washed with ethyl acetate. After drying in a vacuum at 30°C. the product is washed with warm methanol. 45

• Therapeutic Function

  Vasoconstrictor

Ornipressin Upstream-Materialien And Downstream Produkte

Ornipressin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(165)Suppliers

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