Ceftezole

Bezeichnung:Ceftezole

CAS-Nr26973-24-0

Englisch Name:Ceftezole

CBNumberCB6277787

SummenformelC13H12N8O4S3

Molgewicht440.48

MOL-Datei26973-24-0.mol

Ceftezole physikalisch-chemischer Eigenschaften

Schmelzpunkt	155°C (dec.)
Dichte	2.09
storage temp.	Store at -20°C
Löslichkeit	DMSO: 88 mg/mL (199.78 mM);;
pka	2.60±0.50(Predicted)
maximale Wellenlänge (λmax)	273nm(Phosphate buffer sol.)(lit.)
Merck	14,1948
CAS Datenbank	26973-24-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T+,N
R-Sätze:	21/22-26-50/53
S-Sätze:	28-36/37-45-61

Gefahreninformationscode (GHS)

Ceftezole Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Ceftezole,Arocor Holdings Inc.
Verwenden
Ceftezole is a β-lactam, cephem antibiotic. It also exhibits potent α-glucosidase inhibitory activity and antidiabetic effect in streptozotocin-induced mouse.
Verwenden
A direct bandgap semiconductor, it is used in a variety of applications, including radiation detectors, photorefractive gratings, electro-optic modulators, solar cells, and terahertz generation and detection. The band gap varies from approximately 1.4 to 2.2 eV, depending on composition.
Definition
ChEBI: Ceftezole is a first-generation cephalosporin antibiotic having (1,3,4-thiadiazol-2-ylsulfanyl)methyl and [2-(1H-tetrazol-1-yl)acetamido side groups located at positions 3 and 7 respectively. It is a cephalosporin and a member of thiadiazoles.
Manufacturing Process
To a solution of 1 equivalent (eq.) of 1H-tetrazole-1-acetic acid and 1 eq. of triethylamine in 20 ml of tetrahydrofuran cooled to -20°C was added 1 eq. of pivaloyl chloride. After thirty-minute stirring of the mixture 20 ml of a chloroform solution containing 1 eq. of and 1 eq. of triethylamine was poured into the solution cooled at -10°C during a period of 30 minutes. The resulting mixed solution was stirred for 30 minutes at the same temperature, for 1 hour in an ice-water mixture and for 3 hours at room temperature. Removal of a solvent from the reaction mixture afforded an oily residue, which was dissolved into 15 ml of 10% sodium bicarbonate aqueous solution. The resulting aqueous layer was adjusted to pH 1.0-2.0 with 10% hydrochloric acid, washed with ether and extracted with ethyl acetate. The extract was washed with water, dried over sodium sulfate and concentrated under reduced pressure leaving a residue which was triturated with ethyl acetate to obtain 3- acetoxymethyl-8-oxo-7-(2-tetrazol-1-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
A solution of 1 eq. of sodium salt of 3-acetoxymethyl-8-oxo-7-(2-tetrazol-1- acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (it may be prepared with equivalent of sodium bicarbonate and above named acid) and 1 eq. of [1.3.4]-thiadiazole-2-thiol in 20 ml of phosphate buffer (pH 6.4) was stirred for 5.5 hours at 60°C. The reaction mixture was adjusted to pH 2.0 with 5% hydrochloric acid and treated with ethyl acetate to form a title compound - ceftezole.
Therapeutic Function
Antibiotic
Allgemeine Beschreibung
Cadmium zinc telluride (Cd_1-xZn_xTe or CZT) can detect nuclear radiation hence, CZT with Zn concentrations between 0.1-0.2 may be used in the making of radiation detectors of X-ray and gamma-ray spectrometers.

Ceftezole Upstream-Materialien And Downstream Produkte

Ceftezole Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

26973-24-0, Ceftezole Verwandte Suche:

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