(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid

Bezeichnung:(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid

CAS-Nr63-89-8

Englisch Name:1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

CBNumberCB6164209

SummenformelC40H80NO8P

Molgewicht734.04

MOL-Datei63-89-8.mol

Synonyma

(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid

(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid physikalisch-chemischer Eigenschaften

Schmelzpunkt	229-229.5 °C
alpha	D23 +6.6° (c = 4.2 in 1:1 chloroform-methanol)
storage temp.	-20°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Merck	14,2477
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	KILNVBDSWZSGLL-KXQOOQHDSA-N
CAS Datenbank	63-89-8(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
F	10-21
HS Code	29232000

Gefahreninformationscode (GHS)

1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
DPPC, also known as 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine, is a phospholipid containing the 16 carbon fatty acid/palmitic acid (16:0) at the sn-1 and sn-2 positions. It is commonly used in the generation of micelles, liposomes, and other types of artificial membranes. Due to the medium size of fatty acid chain, DLPC is used to form thinner membranes or lipid bilayers.
Chemische Eigenschaften
white powder
Verwenden
16:0 PC (DPPC) is suitable for use:
- in vesicle preparation
- as the main phospholipid component for all ultrasound contrast agents (UCA) formulations
- as a component for microbubble preparation
- in the preparation of lipid bilayers
Verwenden
16:0 PC (DPPC) has been used in the generation of thymoquinone (TQ) liposomes, gold nanorods and calcium chloride encapsulated liposomes and bilayers for biophysical studies.
Verwenden
1,2-dipalmitoyl-sn-glycero-3-phosphocholine is a major phospholipid constituent and primary surface tension lowering component of natural lung surfactant. Colfosceril Palmitate is used as pulmonary surfactant and diagnostic aid (fetal lung maturity).
Definition
ChEBI: A phosphatidylcholine 32:0 in which the 1- and 2-acyl groups are specified as hexadecanoyl (palmitoyl). A synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of pulmonary surfactants.
Allgemeine Beschreibung
Phosphatidylcholine (PC) is a strong bilayer-forming lipid. It the most common phospholipid in mammalian membranes. It is also an important component of the mucosal layer of the colon.
Biochem/physiol Actions
Phosphatidylcholine (PC) functions as a surfactant within the mucus to form a hydrophobic surface to inhibit bacterial penetrance. It is used to treat fat embolism. Phosphatidylcholine lowers the levels of cholesterol and triglycerides.
läuterung methode
It has three crystalline forms 1, 2 and ' which change at 60-70o and at 229o, respectively. In order to obtain a fine powder, ~2 g are dissolved in CHCl3 (15mL) and pet ether (b 35-60o) is added; the solution is evaporated to dryness in vacuo at <20o and then dried at 0.1mm over CaCl2. [Baer & Maurukas J Am Chem Soc 74 158 1952, Baer & Kates J Biol Chem 185 615 1950, Beilstein 4 IV 1463.]

1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Upstream-Materialien And Downstream Produkte

(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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