Fasudil hydrochloride

Bezeichnung:Fasudil hydrochloride

CAS-Nr105628-07-7

Englisch Name:Fasudil hydrochloride

CBNumberCB6101699

SummenformelC14H18ClN3O2S

Molgewicht327.83

MOL-Datei105628-07-7.mol

Fasudil hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	220.5°; mp 219.3° (Shirotani)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	H₂O: >200 mg/mL
Aggregatzustand	solid
Farbe	white
Wasserlöslichkeit	Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.
Merck	14,3942
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChI	InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
InChIKey	LFVPBERIVUNMGV-UHFFFAOYSA-N
SMILES	N1(S(C2=CC=CC3=C2C=CN=C3)(=O)=O)CCCNCC1.[H]Cl.[H]Cl
CAS Datenbank	105628-07-7(CAS DataBase Reference)

Sicherheit

R-Sätze:	22
S-Sätze:	36-60
WGK Germany	3
RTECS-Nr.	HM4031166
HS Code	29339900
Toxizität	LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga)

Gefahreninformationscode (GHS)

Fasudil hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Fasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed for the treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase C. In contrast to other calcium channel blockers, which regulate the influx of calcium ions through the cell membrane but not involved in the intracellular regulatory mechanism of the calcium, fasudil was suggested to have an intracellular mode of action in relaxing vascular smooth muscle. In patients with neurological deficits due to vasospasm, fasudil decreased the occurrence of angiographic severe and symptomatic vasospasm and cerebral infarction without decreasing systemic blood pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of cerebral vascular diseases and angina pectoris.
Originator
Asahi Chemical (Japan)
Verwenden
Fasudil monohydrochloride is used in the prevention and treating cardiovascular and cerebrovascular diseases. It is also used in the inhibition of proliferation of vascular smooth muscle cells. It serves as a selective Rho-associated protein kinase (ROCK) inhibitor. Further, it protects against methyl mercury-induced axonal degeneration.
Verwenden
vasodilator, potent Rho-kinase inhibitor
Definition
ChEBI: Fasudil hydrochloride is a hydrochloride obtained by reaction of fasudil with one equivalent of hydrochloric acid. It has a role as an antihypertensive agent, a calcium channel blocker, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor, a neuroprotective agent, a nootropic agent and a vasodilator agent. It contains a fasudil(1+).
Trademarks
Eril
Lager
Room temperature
Einzelnachweise
1) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95 2) Anwar et al. (2013), Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed; Vascul. Pharmacol., 58 140 3) Jiang et al. (2012), Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice; Int. J. Mol. Sci., 13 8293

Fasudil hydrochloride Upstream-Materialien And Downstream Produkte

Fasudil hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

105628-07-7, Fasudil hydrochloride Verwandte Suche:

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