3,4-DIHYDROQUINOLIN-2(1H)-ONE

Bezeichnung:3,4-DIHYDROQUINOLIN-2(1H)-ONE

CAS-Nr553-03-7

Englisch Name:3,4-DIHYDROQUINOLIN-2(1H)-ONE

CBNumberCB5772351

SummenformelC9H9NO

Molgewicht147.17

MOL-Datei553-03-7.mol

3,4-DIHYDROQUINOLIN-2(1H)-ONE physikalisch-chemischer Eigenschaften

Schmelzpunkt	165-167 °C (lit.)
Siedepunkt	267.28°C (rough estimate)
Dichte	1.1135 (rough estimate)
Brechungsindex	1.5200 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
Aggregatzustand	Crystalline Powder
pka	14.76±0.20(Predicted)
Farbe	Off-white
Wasserlöslichkeit	Slightly soluble in water.
Sensitive	Light Sensitive
Merck	13,4800
CAS Datenbank	553-03-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38-43
S-Sätze:	26-36/37
RIDADR	2811
WGK Germany	2
Hazard Note	Irritant
HazardClass	6.1(b)
PackingGroup	III
HS Code	29337900

Gefahreninformationscode (GHS)

3,4-DIHYDROQUINOLIN-2(1H)-ONE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
Off-white crystalline powder
Verwenden
3,4-Dihydro-2(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments.
Verwenden
3,4-Dihydro-2-(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments. It is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthesize substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms.
Definition
ChEBI: 3,4-Dihydro-2(1H)-quinolinone is a member of quinolines.
Synthesis Reference(s)
Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
Tetrahedron Letters, 36, p. 125, 1995 DOI: 10.1016/0040-4039(94)02191-D
Allgemeine Beschreibung
Series of 3,4-dihydro-2(1H)-quinolinone derivatives having sigma-1 receptor (σ1R) antagonist activity have been synthesized. 3,4-dihydro-2((1)H)-quinolinones have been synthesized using N-(1′-alkoxy)cyclopropyl-2-haloanilines as starting reagent. Cyclopropane ring expansion in the presence of palladium catalyst is the major step involved in the synthesis. Library of 3,4-dihydro-2(1H)-quinolinones have been synthesized through the rearrangement of β-lactam intermediates on the solid-phase

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