Naringin dihydrochalcone

Bezeichnung:Naringin dihydrochalcone

CAS-Nr18916-17-1

Englisch Name:Naringin dihydrochalcone

CBNumberCB6140982

SummenformelC27H34O14

Molgewicht582.56

MOL-Datei18916-17-1.mol

Naringin dihydrochalcone physikalisch-chemischer Eigenschaften

Schmelzpunkt	131-132°C
Siedepunkt	916.8±65.0 °C(Predicted)
Dichte	1.63±0.1 g/cm3(Predicted)
Dampfdruck	0Pa at 20-50℃
FEMA	4495 \| NARINGIN DIHYDROCHALCONE
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	Soluble in DMSO
pka	6.85±0.40(Predicted)
Aggregatzustand	Powder
Farbe	White to Off-white
JECFA Number	2208
Major Application	food and beverages
InChIKey	CWBZAESOUBENAP-CUDWAMJSNA-N
SMILES	O1[C@H]([C@@H]([C@@H]([C@H]([C@@H]1C)O)O)O)O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O)CO)Oc3cc(c(c(c3)O)C(=O)CCc4ccc(cc4)O)O
LogP	-0.703-1.01 at 22.6℃ and pH5-9
CAS Datenbank	18916-17-1(CAS DataBase Reference)

Sicherheit

WGK Germany	WGK 1
HS Code	29329990
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

Gefahreninformationscode (GHS)

Naringin dihydrochalcone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Naringin dihydrochalcone is an artificial sweetener and flavonoid that has been isolated from various plants and has antioxidant activity. It scavenges ABTS (Item No. 27317), oxygen, and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell free assays (IC50s = 24, 322.8, and 318.9 μM, respectively).
Verwenden
Naringin Dihydrochalcone is an intense sweetener and strong antioxidant compound which displays anti-allegeric activity.
Definition
ChEBI: Naringin dihydrochalcone is a member of flavonoids and a glycoside.
Synthese

10236-47-2

18916-17-1

Naringin was used as a raw material to synthesize 1-(4-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,6-dihydroxyphenyl)-3-( 4-hydroxyphenyl)propan-1-one was prepared in the following general procedure: 120 g of the natural extract (containing 600 g of 8% naringin) was dissolved in potassium hydroxide solution and filtered to obtain a clarified solution. The filtrate was transferred to a 2000 ml autoclave and 200 g of ethanol and 3 g of palladium carbon catalyst were added. Hydrogen was introduced at 55°C, maintaining the pressure at 1~2MPa, and the reaction was carried out for 5~7 hours until the hydrogen absorption was basically completed. The reaction solution was removed and filtered to remove the palladium-carbon catalyst. Subsequently, the hydrogenated solution was acidified with hydrochloric acid, the pH was adjusted to 5-7, and stirred thoroughly to induce crystallization, and a white solid was rapidly precipitated. The mixture was cooled to 20 °C and filtered, and the resulting wet product was dried under reduced pressure at 60 °C to give 118 g of dihydronaringenin chalcone as a white powder with 98.9% liquid phase purity and 98% molar yield. The product needs to be stored in a cool place under light nitrogen protection.
target
NF-κB
Einzelnachweise
[1] Patent: CN105801636, 2016, A. Location in patent: Paragraph 0022
[2] Journal of Agricultural and Food Chemistry, 2003, vol. 51, # 11, p. 3309 - 3312

Naringin dihydrochalcone Upstream-Materialien And Downstream Produkte

Naringin dihydrochalcone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

18916-17-1, Naringin dihydrochalcone Verwandte Suche:

Send Inquriy