Indan-1-on

Bezeichnung:Indan-1-on

CAS-Nr83-33-0

Englisch Name:1-Indanone

CBNumberCB0384120

SummenformelC9H8O

Molgewicht132.16

MOL-Datei83-33-0.mol

Synonyma

Indan-1-on

Indan-1-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	38-40 °C(lit.)
Siedepunkt	243-245 °C(lit.)
Dichte	1.103 g/mL at 25 °C(lit.)
Brechungsindex	1.5610 (estimate)
Flammpunkt	233 °F
storage temp.	Store below +30°C.
Löslichkeit	6.5g/l
Aggregatzustand	Crystalline Mass
Farbe	Light yellow to brown
Geruch (Odor)	Rather weak, woody and somewhat medicinal odor with an incense-like undertone.
Odor Threshold	0.0088ppm
Biologische Quelle	mouse
Wasserlöslichkeit	6.5 g/L (20 C)
BRN	507957
Stabilität	Light sensitive
InChI	1S/C9H8O/c10-9-6-5-7-3-1-2-4-8(7)9/h1-4H,5-6H2
InChIKey	QNXSIUBBGPHDDE-UHFFFAOYSA-N
SMILES	O=C1CCc2ccccc12
CAS Datenbank	83-33-0(CAS DataBase Reference)
NIST chemische Informationen	1H-Inden-1-one, 2,3-dihydro-(83-33-0)
EPA chemische Informationen	1H-Inden-1-one, 2,3-dihydro- (83-33-0)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	22-24/25-36-26
WGK Germany	3
Selbstentzündungstemperatur	525 °C
Hazard Note	Irritant
TSCA	TSCA listed
HS Code	29143900
Speicherklasse	11 - Combustible Solids

Gefahreninformationscode (GHS)

1-Indanone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
1-Indanone is an important skeletal structure with a wide range of biological activities. Extensive research has demonstrated that 1-indanone derivatives play a significant role in the development of drugs for the treatment of Alzheimer's disease, as well as in anti-diarrhoeal, anti-proliferative, antibacterial, anti-inflammatory and anti-cancer agents^[1].
Chemische Eigenschaften
Pale yellow liquid
Verwenden
1-Indanone is an oxidation product of Indan, a component of fuels, solvents, and varnishes. 1-Indanone is also a metabolite of Thalidomide that has been shown to inhibit the attachment of tumor cells to concanavalin A coated plastic surfaces.
Verwenden
1-Indanone is an oxidation product of indan, a component of fuels, solvents and varnishes. 1-Indanone is also a metabolite of Thalidomide that has been shown to inhibit the attachment of tumor cells to concanavalin A coated plastic surfaces.
Definition
ChEBI: An indanone that consists of 2,3-dihydro-1H-indene substituted by an oxo group at position 1.
Synthesis Reference(s)
The Journal of Organic Chemistry, 54, p. 1144, 1989 DOI: 10.1021/jo00266a028
Journal of the American Chemical Society, 99, p. 4822, 1977 DOI: 10.1021/ja00456a048
Tetrahedron Letters, 27, p. 3139, 1986 DOI: 10.1016/S0040-4039(00)84736-X
Biologische Aktivität
Indoleamine 2,3 dioxygenase (IDO) 1 plays an important role in the metabolism of tryptophan and in immune regulation. Removal of IDO1 results in attenuated contact hypersensitivity (CHS) responses.
Synthese
1-Indanone is produced by cyclization of be{a-Phenylpropionyl chloride in Benzene.
Einzelnachweise
[1] Mei Zuo . (2025). Synthesis, X-ray, DFT and antibacterial activity of a novel 1-indanone derivative. Journal of Molecular Structure, 1339, Article 142422. https://doi.org/10.1016/j.molstruc.2025.142422

1-Indanone Upstream-Materialien And Downstream Produkte

Indan-1-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

83-33-0, 1-Indanone Verwandte Suche:

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