2-Brom-6-methylpyridin

Bezeichnung:2-Brom-6-methylpyridin

CAS-Nr5315-25-3

Englisch Name:2-Bromo-6-methylpyridine

CBNumberCB5770908

SummenformelC6H6BrN

Molgewicht172.02

MOL-Datei5315-25-3.mol

Synonyma

2-Brom-6-methylpyridin

2-Brom-6-methylpyridin physikalisch-chemischer Eigenschaften

Siedepunkt	102-103 °C/20 mmHg (lit.)
Dichte	1.512 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.562(lit.)
Flammpunkt	207 °F
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Chloroform, Ethyl Aceate
pka	1.51±0.10(Predicted)
Aggregatzustand	Liquid
Farbe	Clear colorless to yellow
Wichte	1.512
Wasserlöslichkeit	Soluble in chloroform, ethyl aceate. Not miscible or difficult to mix with water.
BRN	107322
InChI	InChI=1S/C6H6BrN/c1-5-3-2-4-6(7)8-5/h2-4H,1H3
InChIKey	SOHDPICLICFSOP-UHFFFAOYSA-N
SMILES	C1(Br)=NC(C)=CC=C1
CAS Datenbank	5315-25-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333990
Speicherklasse	10 - Combustible liquids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

2-Bromo-6-methylpyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Light yellow liquid
Verwenden
2-Bromo-6-methylpyridine may be used in the synthesis of the following:
- 6,6′-dimethyl-2,2′-bipyridine
- 6-methyl-2-pyridyl-2-pyridylmethanone
- 2-methyl-6-(trimethylsilyl)-pyridine
- N,N′-bis-(6-methylpyrid-2-yl)-(1R,2R)-1,2- diaminocyclohexane (cydiampy)
- 2-methyl-6-(trimethylstannanyl)pyridine
- 2-(6-methylpyridin-2-yl)propan-2-ol
- bis[(2-bromo-6-methylpyridinium)hexafluorosilicate] monohydrate
Verwenden
2-Bromo-6-methylpyridine is a halogenated pyridine derivative used is a building block in the preparation of nitrogen containing heterocyclic compounds.
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 3168, 1954 DOI: 10.1021/ja01641a017
Allgemeine Beschreibung
2-Bromo-6-methylpyridine is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
Synthese
The following are the steps for preparing 2-Bromo-6-methylpyridine:
Step 1: 2-Amino-6-methylpyridine With hydrogen bromide; bromine at -10~5℃ for 1.5h;
Step 2: With NaNO2 In water monomer at -10~5℃ for 1.5h;
Step 3: With sodium hydroxide In water monomer at -10℃.
Einzelnachweise
[1] Patent: CN105384684, 2016, A. Location in patent: Paragraph 0028; 0029
[2] Organic Letters, 2000, vol. 2, # 21, p. 3373 - 3376
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2002, vol. 177, # 11, p. 2579 - 2587
[4] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[5] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 19, p. 3151 - 3155

2-Bromo-6-methylpyridine Upstream-Materialien And Downstream Produkte

2-Brom-6-methylpyridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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