Dinatrium-(1R,2S)-(1,2-epoxypropyl)phosphonat

Bezeichnung:Dinatrium-(1R,2S)-(1,2-epoxypropyl)phosphonat

CAS-Nr26016-99-9

Englisch Name:Disodium phosphonomycin

CBNumberCB5761937

SummenformelC3H8NaO4P

Molgewicht162.06

MOL-Datei26016-99-9.mol

Synonyma

Dinatrium-(1R,2S)-(1,2-epoxypropyl)phosphonat

Dinatrium-(1R,2S)-(1,2-epoxypropyl)phosphonat physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300°C
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	H₂O: 50 mg/mL, clear, colorless
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	Freely soluble in water or aqueous solution
BRN	4604425
Stabilität	Hygroscopic
InChI	InChI=1/C3H7O4P.Na.H/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/t2-,3+;;/s3
InChIKey	QZIQJIKUVJMTDG-OTUWWBTESA-L
SMILES	P([C@H]1O[C@H]1C)(O)(O)=O.[NaH] \|&1:1,3,r\|
CAS Datenbank	26016-99-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	F,C
R-Sätze:	11-34
S-Sätze:	16-26-36/37/39-45
WGK Germany	2
RTECS-Nr.	SZ7902000
F	10-21
HS Code	29419090

Gefahreninformationscode (GHS)

Disodium phosphonomycin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White Solid
Verwenden
Disodium phosphonomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine
Verwenden
Prevents peptidoglycan synthesis by inhibiting MurA, an enzyme responsible for synthesizing N-acetylmuramic acid or NAM, a major component of peptidoglycan
Verwenden
Curariform muscle relaxants
Biologische Aktivität
Antibiotic th at concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin is a phosphoenolpyruvate analog th at irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. As a result, the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall, is inhibited.

in vivo

Fosfomycin sodium (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes^[3].
Pharmacokinetic of Fosfomycin sodium in Rats^[4]

Dibekacin Dose (mg)	V_dss (l/kg)	β (min^-1)	T_1/2 (min)	Urinary recovery (%)
30	0.261	0.0244	28.4	85

Animal Model:	Fischer 344 rats^[3]
Dosage:	320 mg/kg
Administration:	Intramuscular injection, 5 schedules: 1 h, 0.5 h earlier than dibekacin, concomitantly, 0.5 h later and 1 h later; 11 days
Result:	Reduced polyuria, proteinuria, enzymes and cytosine caused by dibecacin (40 mg/kg), followed by the previous treatment.

Animal Model:	Dehydrated Wistar rat with acute renal failure (8-week-old)^[4]
Dosage:	120 mg/kg
Administration:	Intravenous injection; once
Result:	Recovered the exclusion rate of rats basically to normal, and improved the nephrotoxicity parameters. Protects proximal tubular lysosomes from aminoglycosides by inhibiting myeloid formation and protecting the integrity of lysosomal membrane of rats treated with double bekacin.

Dinatrium-(1R,2S)-(1,2-epoxypropyl)phosphonat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

26016-99-9, Disodium phosphonomycin Verwandte Suche:

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