Carmofur

Bezeichnung:Carmofur

CAS-Nr61422-45-5

Englisch Name:Carmofur

CBNumberCB5748051

SummenformelC11H16FN3O3

Molgewicht257.26

MOL-Datei61422-45-5.mol

Carmofur physikalisch-chemischer Eigenschaften

Schmelzpunkt	110-111
Dichte	1.2287 (estimate)
storage temp.	2-8°C
Löslichkeit	DMSO: >15mg/mL
Aggregatzustand	powder
pka	6.94±0.10(Predicted)
Farbe	white to off-white
Merck	14,1844
CAS Datenbank	61422-45-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,T
R-Sätze:	60-61-25
S-Sätze:	45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	3
RTECS-Nr.	UV7714000
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29335990

Gefahreninformationscode (GHS)

Carmofur Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Carmofur is an inhibitor of acid ceramidase (IC₅₀ = 79 nM for the rat enzyme) and a derivative of 5-flurouracil . It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide , C16 ceramide , and C14 ceramide in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC₅₀ = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.
Originator
Mifurol,Mitsui,Japan,1981
Verwenden
antineoplastic
Verwenden
Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .
Definition
ChEBI: Carmofur is an organohalogen compound and a member of pyrimidines.
Manufacturing Process
13.0 g (0.10 mol) of 5-fluorouracil was suspended in 60 ml of dimethyl acetamide, then 14.0 g (0.11 mol) of n-hexyl isocyanate was added thereto at room temperature and stirred at 50°C for 8 hours. After the reaction mixture was concentrated under reduced pressure, the residue was poured into 400 ml of water and resultant precipitate was filtered off. The precipitate was washed and dried and 19.3 g (75.0% yield) of 5-fluoro-1-(n-hexylcarbamoyl)uracil was obtained.
The product was recrystallized from ether and there were obtained white crystals melting at 283°C (decomposition).
Therapeutic Function
Antineoplastic
Biochem/physiol Actions
Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Carmofur Upstream-Materialien And Downstream Produkte

Carmofur Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

61422-45-5, Carmofur Verwandte Suche:

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