Phentolaminmesilat

Bezeichnung:Phentolaminmesilat

CAS-Nr65-28-1

Englisch Name:Phentolamine mesilate

CBNumberCB5708736

SummenformelC18H23N3O4S

Molgewicht377.46

MOL-Datei65-28-1.mol

Synonyma

Phentolaminmesilat

Phentolaminmesilat physikalisch-chemischer Eigenschaften

Schmelzpunkt	180-182 °C(lit.)
Dichte	1.2256 (rough estimate)
Brechungsindex	1.6320 (estimate)
storage temp.	2-8°C
Löslichkeit	ethanol: 26 mg/mL
Aggregatzustand	powder
Farbe	white to off-white
Wasserlöslichkeit	50 mg/mL
Merck	14,7264
Stabilität	Aq. Solutions Cannot be Stored
InChI	InChI=1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChIKey	OGIYDFVHFQEFKQ-UHFFFAOYSA-N
SMILES	N(CC1=NCCN1)(C1C=CC(C)=CC=1)C1C=CC=C(O)C=1.S(=O)(=O)(O)C

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21/22-36/37/38
S-Sätze:	26-36
RIDADR	3249
WGK Germany	3
RTECS-Nr.	SL5430000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29332900
Toxizität	LDLo scu-rat: 275 mg/kg NIIRDN 6,667,82

Gefahreninformationscode (GHS)

Phentolamine mesilate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Phentolamine mesylate is a white, odourless powder which is soluble in water and alcohol.
Verwenden
Phentolamine mesilate is an adrenergic blocking agent and antihypertensive. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
Trademarks
Regitine (Novartis) [Name previously used: Phentolamine Methanesulfonate.].
Allgemeine Beschreibung
Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis.
Biochem/physiol Actions
α-Adrenergic receptor antagonist; peripheral vasodilator.
Clinical Use
Alpha-adrenoceptor blocker:
Hypertensive crisis
Sicherheitsprofil
Poison by intravenous and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: additive hypotensive effect with MAOIs - avoid.
Antihypertensives: enhanced hypotensive effect.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect - avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Linezolid: additive hypotensive effect.
Moxisylyte: possibly severe postural hypotension.
Stoffwechsel
Phentolamine is extensively metabolised.
Only about 10-13% of an intravenous dose is excreted unchanged in the urine, and the fate of the remainder of the drug is unknown.
Lager
Store at +4°C
Mode of action
Phentolamine Mesylate is the mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.

Phentolamine mesilate Upstream-Materialien And Downstream Produkte

Phentolaminmesilat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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