Megestrol

Bezeichnung:Megestrol

CAS-Nr3562-63-8

Englisch Name:Megestrol

CBNumberCB5465978

SummenformelC22H30O3

Molgewicht342.47

MOL-Datei3562-63-8.mol

Synonyma

Megestrol

Megestrol physikalisch-chemischer Eigenschaften

Schmelzpunkt	207-208 °C(Solv: ethyl ether (60-29-7); acetone (67-64-1))
Siedepunkt	500.4±50.0 °C(Predicted)
Dichte	1.15±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	13.00±0.70(Predicted)
Farbe	White to Off-White
CAS Datenbank	3562-63-8(CAS DataBase Reference)

Sicherheit

Giftige Stoffe Daten

3562-63-8(Hazardous Substances Data)

Megestrol Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White Solid
Verwenden
Megestrol is an orally active progestogen. Megestrol is used in combinations as oral contraceptive and as antineoplastic agent.
Indications
As a representitive of the compounds of the class of progestins, this drug is used for various forms of cancer, in particular cancer of the breast, kidneys, and others.
Definition
ChEBI: A 3-oxo Delta4-steroid that is pregna-4,6-diene-3,20-dione substituted by a hydroxy group at position 17.
Trademarks
Megace (Bristol-Myers Squibb); Megace (Par);Citestrol;Co-ervonum;Combiquens;Femagest;Kombiquens;Megecat;Megeron;Megestat;Menoquens;Neo-delpregnin;Niaestine;Niagestine;Novaquin;Novokvens;Novolina;Novoquens;Oracolnal;Ovaban;Ovarid;Pallace;Serial 28;Volidan;Volplan.
Weltgesundheitsorganisation (WHO)
Megestrol acetate, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, megestrol acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and megestrol remains available in some countries for contraceptive purposes. In other countries its use is restricted to anticancer treatment. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)
Synthese
Megestrol, 17|á-hydroxy-6|á-methylpregna-4,6-dien-3,20-dione acetate (28.3.9), is a product of dehydrogenation medroxyprogesterone (28.3.7) with chloranil (tetrachloro-p-benzoquinone) in the presence of p-toluenesulfonic acid, which results in the formation of an additional double bond at position C6¨CC7, and subsequent acetylation of the product (28.3.8) leads to the desired megestrol (28.3.9) by acetic anhydride in the presence of p-toluenesulfonic acid.

Megestrol Upstream-Materialien And Downstream Produkte

Megestrol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3562-63-8, Megestrol Verwandte Suche:

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