4-Cyanophenylhydrazine hydrochloride

Bezeichnung:4-Cyanophenylhydrazine hydrochloride

CAS-Nr2863-98-1

Englisch Name:4-Cyanophenylhydrazine hydrochloride

CBNumberCB5284560

SummenformelC7H8ClN3

Molgewicht169.61

MOL-Datei2863-98-1.mol

4-Cyanophenylhydrazine hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	241-244 °C (dec.)(lit.)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Soluble in methanol.
Aggregatzustand	Powder
Farbe	Pale orange to brown
Sensitive	Moisture Sensitive
BRN	3565486
InChI	InChI=1S/C7H7N3.ClH/c8-5-6-1-3-7(10-9)4-2-6;/h1-4,10H,9H2;1H
InChIKey	UXDLLFIRCVPPQP-UHFFFAOYSA-N
SMILES	C1(C#N)=CC=C(NN)C=C1.Cl
CAS Datenbank	2863-98-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36/37/38
S-Sätze:	26-36-36/37/39
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
Hazard Note	Harmful
PackingGroup	III
HS Code	29280000
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

4-Cyanophenylhydrazine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Pale orange to brown powder
Verwenden
4-Cyanophenylhydrazine Hydrochloride (cas# 2863-98-1) is a compound useful in organic synthesis.
Synthese

873-74-5

2863-98-1

The general procedure for the synthesis of 4-cyanophenylhydrazine hydrochloride from 4-aminobenzonitrile was as follows: to a stirring suspension of 4-aminobenzonitrile (50 g, 423 mmol) concentrated hydrochloric acid (550 mL) was slowly added dropwise an aqueous sodium nitrite solution (31.5 g, 457 mmol, dissolved in 200 mL of water) at a low temperature of -5 to 0 °C. Keeping the reaction temperature below 0 °C, a solution of tin(II) chloride dihydrate (477 g, 2.1 mol) concentrated hydrochloric acid (370 mL) pre-cooled to 0 °C was added to the above diazotized solution. The reaction mixture was continued to be stirred for 15 minutes. Upon completion of the reaction, the resulting white precipitate was collected by filtration, washed with diethyl ether and recrystallized from aqueous ethanol. The resulting 4-cyanophenylhydrazine hydrochloride had a melting point of 234-236 °C (literature value 235-237 °C) and yielded 60 g in 84% yield.
Einzelnachweise
[1] Journal of the American Chemical Society, 2016, vol. 138, # 30, p. 9377 - 9380
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 15, p. 4581 - 4590
[3] Synthetic Communications, 2014, vol. 44, # 24, p. 3563 - 3571
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 19, p. 3023 - 3032
[5] Angewandte Chemie - International Edition, 2013, vol. 52, # 47, p. 12426 - 12429

4-Cyanophenylhydrazine hydrochloride Upstream-Materialien And Downstream Produkte

4-Cyanophenylhydrazine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2863-98-1, 4-Cyanophenylhydrazine hydrochloride Verwandte Suche:

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