Nelfinavir mesylate

Bezeichnung:Nelfinavir mesylate

CAS-Nr159989-65-8

Englisch Name:Nelfinavir mesylate

CBNumberCB5213805

SummenformelC33H49N3O7S2

Molgewicht663.89

MOL-Datei159989-65-8.mol

Nelfinavir mesylate physikalisch-chemischer Eigenschaften

Schmelzpunkt	131-135°C
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	DMSO: ≥2mg/mL
pka	pKa -1.20(at 25℃)
Aggregatzustand	powder
Farbe	white to off-white
Wasserlöslichkeit	4.5g/L(temperature not stated)
Merck	14,6443
BCS Class	2,4
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey	NQHXCOAXSHGTIA-SKXNDZRYSA-N
CAS Datenbank	159989-65-8(CAS DataBase Reference)

Sicherheit

WGK Germany	3
RTECS-Nr.	NW6995333
HS Code	29334900
Giftige Stoffe Daten	159989-65-8(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Nelfinavir mesylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Viracept was launched in the US as an orally-available, non-peptidic HIV protease inhibitor. It is prepared in an eight step synthesis beginning with N- (benzyloxycarbonyl)-L-serine β-lactone. The HIV protease inhibitory activity blocks the processing of gag and gagpol polyproteins that are required for viral maturation. It was discovered based on an experimentally derived 3D-structure of HIV-1 protease. Viracept has a high oral bioavailability, lacks toxicity, and has a resistance profile different from other protease inhibitors. Viracept with ziduvudine and larnivudine generated a 98% mean reduction from baseline in viral load after 24 weeks compared to ziduvudine and larnivudine alone. Viracept also had better CD4 counts and is available in adult and pediatric formulations.
Chemische Eigenschaften
White Powder
Originator
Agouron (US)
Verwenden
Nelfinavir Mesylate is an antiviral. HIV protease inhibitor. It is a COVID19-related research product.
Definition
ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of nelfinavir and methanesulfonic acid. It is used for treatment of HIV and also exhibits some anticancer properties.
Trademarks
Viracept (Agouron).
Biologische Aktivität
Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (K i = 2 nM) in vitro .
Biochem/physiol Actions
Nelfinavir mesylate hydrate, also known as AG1343, is used as a therapeutic agent for acquired immunodeficiency syndrome (AIDS). It acts as an antifibrotic agent and is used to treat pulmonary fibrosis in patients with systemic sclerosis (SSc). In addition, nelfinavir mesylate hydrate reduces inflammation by activating protein phosphatase 2 (PP-2) and blocking mitogen-activated protein kinases (MAPK) signaling in macrophages. It also stimulate autophagy and exhibit anti-cancer property.
Lager
Store at +4°C
Einzelnachweise
1) Olmo?et al.?(2006),?A review of nelfinavir for the treatment of HIV infection; Expert Opin. Drug Metab. Toxicol.,?2?285 2) Bruning?et al.?(2010),?New prospects for nelfinavir in non-HIV-related diseases; Curr. Mol. Pharmacol.,?3?91 3) Gills?et al.?(2007),?Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo; Clin. Cancer Res,?13?5183 4) Shim?et al. (2012),?Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir; J. Natl. Cancer Inst,,?104?1576

Nelfinavir mesylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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