Benfotiamine Struktur

Benfotiamin

Bezeichnung:Benfotiamin

CAS-Nr22457-89-2

Englisch Name:Benfotiamine

CBNumberCB4775966

SummenformelC19H23N4O6PS

Molgewicht466.45

MOL-Datei22457-89-2.mol

Synonyma

Benfotiamin

Benfotiamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	165 C
Siedepunkt	745.1±70.0 °C(Predicted)
Dichte	1.444±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Aqueous Acid (Slightly), DMSO (Heated, Sonicated)
Aggregatzustand	Solid
pka	1.84±0.10(Predicted)
Farbe	White to Off-White
Merck	14,1041
Stabilität	Hygroscopic
InChIKey	BTNNPSLJPBRMLZ-GHRIWEEISA-N
SMILES	C(C1=CN=C(C)N=C1N)N(C=O)C(C)=C(CCOP(O)(O)=O)SC(C1C=CC=CC=1)=O
LogP	-2.814 (est)
CAS Datenbank	22457-89-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36/37/38
S-Sätze:	26-36
WGK Germany	2
RTECS-Nr.	DH6910000
HS Code	2933.59.8000

Gefahreninformationscode (GHS)

Benfotiamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
crystals
Originator
Biotamin,Sankyo
Verwenden
Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).
Verwenden
S-Benzoylthiamine O-monophosphate has been used to determine its effect on ischemia and reperfusion in skeletal muscles of rat.
Definition
ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Manufacturing Process
28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated.
The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition).
Therapeutic Function
Analgesic
Allgemeine Beschreibung
S-Benzoylthiamine O-monophosphate (Benfotiamine) is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine?contains a thiazole ring. Benfotiamine has a greater bioavailability than thiamine.
Biochem/physiol Actions
S-Benzoylthiamine O-monophosphate (Benfotiamine) is a therapeutic agent. It helps in the prevention of diabetic complications such as, retinopathy, neuropathy and nephropathy. Benfotiamine inhibits the synthesis of glycation end products (AGEs) in diabetes. Benfotiamine is considered as a nutraceutical product for the prevention of diabetic neuropathy.

Benfotiamine Upstream-Materialien And Downstream Produkte

Benfotiamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

22457-89-2, Benfotiamine Verwandte Suche:

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