Fursultiamin

Bezeichnung:Fursultiamin

CAS-Nr804-30-8

Englisch Name:Fursultiamine

CBNumberCB1161096

SummenformelC17H26N4O3S2

Molgewicht398.54

MOL-Datei804-30-8.mol

Synonyma

Fursultiamin

Fursultiamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	130-136°C (decompos.)
Siedepunkt	652.3±55.0 °C(Predicted)
Dichte	1.29
Brechungsindex	1.6270 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
Aggregatzustand	Solid
pka	14.42±0.10(Predicted)
Farbe	White to Off-White
CAS Datenbank	804-30-8(CAS DataBase Reference)

Sicherheit

Toxizität

LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi)

Fursultiamine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Fursultiamine (syn. thiamine tetrahydrofurfuryl disulfide) is a vitamin B1 derivative which is rarely used, is only sparingly soluble in water and thus is usually employed only for solid drug forms. Lyophilisates are stabilized by sodium dextran sulfate.
Chemische Eigenschaften
white or slightly yellow crystalline powder. melting point 130-136 °C (decomposition). soluble in methanol, ethanol, chloroform, slightly soluble in acetone, insoluble in benzene, ether, slightly garlic odor.
Originator
Alinamin F,Takeda,Japan,1961
Verwenden
Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.
Application
Fursultiamine, a lipophilic vitamin B1 derivative, which is more readily absorbed in large amounts in the small intestine and has a longer half-life than its active counterpart vitamin B1. It is suitable for the treatment of beriberi or Wernicke encephalopathy due to vitamin B1 deficiency. It can also be used for the adjuvant treatment of peripheral neuritis and indigestion caused by vitamin B1 deficiency.
synthetische
Furanthiamine is obtained by condensing thiamine hydrochloride with sodium tetrahydrofuranmethyl thiosulfate after ring opening.
Definition
ChEBI: Fursultiamine is a member of pyrimidines.
Manufacturing Process
To a solution of 20 parts of thiamine hydrochloride in 30 parts of water is added an aqueous solution of sodium hydroxide (7.2 parts of NaOH in 30 parts of water), and the mixture is cooled with water. The mixture is allowed to stand for 30 minutes, 60 parts of chloroform is added, followed by a solution of 30 parts of crude sodium tetrahydrofurfurylthiosulfate in 30 parts of water, and the whole is stirred for 30 minutes. The chloroform layer is separated and the aqueous layer is extracted twice with 20 parts of chloroform. All the chloroform solutions are combined and shaken with 50 parts of 5% hydrochloric acid. The acid solution is decolorized and neutralized with alkali carbonate, whereupon thiamine tetrahydrofurfuryl disulfide separates out in the resinous state but soon solidifies [MP 129°C (decamp.)] . The yield is 16 parts. Recrystallization from ethyl acetate gives colorless prisms melting at 132°C (decomp.).
Therapeutic Function
Enzyme cofactor vitamin

Fursultiamine Upstream-Materialien And Downstream Produkte

Fursultiamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

804-30-8, Fursultiamine Verwandte Suche:

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