Tolbutamid Produkt Beschreibung

TOLBUTAMIDE Struktur
64-77-7
  • CAS-Nr.64-77-7
  • Bezeichnung:Tolbutamid
  • Englisch Name:TOLBUTAMIDE
  • Synonyma:Tolbutamid
    IRKG;d860;IRK16;GIRK4;BZ 55;D 860;u2043;KCNJ16;Diaben;Drabet
  • CBNumber:CB4709039
  • Summenformel:C12H18N2O3S
  • Molgewicht:270.35
  • MOL-Datei:64-77-7.mol
Tolbutamid physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :128-130°C
  • Dichte :1.2450
  • Brechungsindex :1.6360 (estimate)
  • storage temp.  :Refrigerator
  • Löslichkeit :Soluble in chloroform.
  • pka :pKa 5.32(H2O t = 37) (Uncertain)
  • Aggregatzustand :neat
  • Merck  :14,9507
  • BRN  :1984428
  • Stabilität: :Stable. Combustible.
  • CAS Datenbank :64-77-7(CAS DataBase Reference)
Sicherheit

TOLBUTAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
    R40:Verdacht auf krebserzeugende Wirkung.
    R43:Sensibilisierung durch Hautkontakt möglich.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  • Chemische Eigenschaften White or almost white, crystalline powder.
  • Verwenden An antidiabetic, used as a hypoglycemic agent in veterinary medicine.
  • Definition ChEBI: An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
  • Allgemeine Beschreibung Tolbutamide is N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide;or 1-butyl-3-(p-tolylsulfonyl)urea (Orinase,generic). Orinase Diagnostic was the sodium salt, which isfreely soluble in water for injection, but this product was discontinuedc. 2000.
  • Allgemeine Beschreibung Tolbutamide, 1-butyl-3-(p-tolylsulfonyl)urea (Orinase), occurs as a white, crystalline powderthat is insoluble in water and soluble in alcohol or aqueousalkali. It is stable in air.
    Tolbutamide is absorbed rapidly in responsive diabetic patients.The blood sugar level reaches a minimum after 5 to8 hours. It is oxidized rapidly in vivo to 1-butyl-3-(p-carboxyphenyl)sulfonylurea, which is inactive. The metabolite isfreely soluble at urinary pH; if the urine is strongly acidified,however, as in the use of sulfosalicylic acid as a protein precipitant,a white precipitate of the free acid may be formed.
  • Allgemeine Beschreibung White crystals.
  • Air & Water Reaktionen Insoluble in water.
  • Reaktivität anzeigen TOLBUTAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). TOLBUTAMIDE is incompatible with acids. .
  • Brandgefahr Flash point data for TOLBUTAMIDE are not available. TOLBUTAMIDE is probably combustible.
  • Clinical Use Tolbutamide should be used only when the diabetic patientis an adult or shows adult-onset diabetes, and the patientshould adhere to dietary restrictions.
  • Sicherheitsprofil Moderately toxic by ingestion and several other routes. A human teratogen. Human reproductive effects by ingestion and possibly other routes: stillbirth, developmental abnormalities of the cardlovascular (circulatory) system and urogenital system, and unspecified neonatal effects. Human systemic effects by ingestion: nausea or vomiting, hypoglycemia. Other experimental teratogenic and reproductive effects. Mutation data reported. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of NO, and SOx.
TOLBUTAMIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tolbutamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global(141)Suppliers
  • Firmenname:Mainchem Co., Ltd.
  • Telefon:+86-0592-6210733
  • Fax:+86-0592-6210733
  • E-Mail:sales@mainchem.com
  • Land:CHINA
  • Produktkatalog:32447
  • Edge Rate:55
  • Firmenname:career henan chemical co
  • Telefon:+86-371-86658258
  • Fax:
  • E-Mail:sales@coreychem.com
  • Land:CHINA
  • Produktkatalog:29979
  • Edge Rate:58
  • Firmenname:Chemwill Asia Co.,Ltd.
  • Telefon:86-21-51086038
  • Fax:86-21-51861608
  • E-Mail:chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com
  • Land:CHINA
  • Produktkatalog:23978
  • Edge Rate:58
  • Firmenname:Hubei Jusheng Technology Co.,Ltd.
  • Telefon:86-18871470254
  • Fax:027-59599243
  • E-Mail:sales@jushengtech.com
  • Land:CHINA
  • Produktkatalog:28236
  • Edge Rate:58
  • Firmenname:Hubei xin bonus chemical co. LTD
  • Telefon:86-13657291602
  • Fax:027-59338440
  • E-Mail:sales@guangaobio.com
  • Land:CHINA
  • Produktkatalog:23049
  • Edge Rate:58
  • Firmenname:BOC Sciences
  • Telefon:1-631-619-7922
  • Fax:1-631-614-7828
  • E-Mail:inquiry@bocsci.com
  • Land:United States
  • Produktkatalog:20115
  • Edge Rate:58
  • Firmenname:Chongqing Chemdad Co., Ltd
  • Telefon:+86-13650506873
  • Fax:
  • E-Mail:sales@chemdad.com
  • Land:CHINA
  • Produktkatalog:30864
  • Edge Rate:58
  • Firmenname:Shanghai Boyle Chemical Co., Ltd.
  • Telefon:Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
  • Fax:+86-21-57758967
  • E-Mail:sales@boylechem.com
  • Land:China
  • Produktkatalog:2214
  • Edge Rate:55
  • Firmenname:J & K SCIENTIFIC LTD.
  • Telefon:400-666-7788 +86-10-82848833
  • Fax:86-10-82849933
  • E-Mail:jkinfo@jkchemical.com;market6@jkchemical.com
  • Land:China
  • Produktkatalog:96815
  • Edge Rate:76
  • Firmenname:Meryer (Shanghai) Chemical Technology Co., Ltd.
  • Telefon:+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
  • Fax:+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)
  • E-Mail:sh@meryer.com
  • Land:China
  • Produktkatalog:40269
  • Edge Rate:62
64-77-7, TOLBUTAMIDE Verwandte Suche:
  • LABOTEST-BB LT00772316
  • 3-[P-TOLYL-4-SULFONYL]-1-BUTYLUREA
  • 1-BUTYL-3-(P-TOLYLSULFONYL)UREA
  • 1-BUTYL-3-(4-METHYLBENZENESULFONYL)UREA
  • 1-BUTYL-3-(4-METHYLPHENYLSULFONYL)UREA
  • 1-N-BUTYL-3-(P-TOLYLSULFONYL)UREA
  • TOLUINA
  • TOLBUTAMIDE
  • TOLBUTAMIDE, [CARBONYL-14C]
  • ORINASE
  • N-4-METHYLBENZENESULFONYL-N'-BUTYL UREA
  • N-[(BUTYLAMINO)CARBONYL]-4-METHYLBENZENE-SULFONAMIDE
  • 1-(([(Butylamino)carbonyl]amino)sulfonyl)-4-methylbenzene
  • 1-Butyl-3-(para-tolylsulfonyl)-urea
  • 1-Butyl-3-(para-tolysulfonyl)urea
  • 1-Butyl-3-(p-methylphenylsulfonyl)urea
  • 1-butyl-3-(p-tolylsulfonyl)-ure
  • 1-Butyl-3-tosylurea
  • 1-p-Toluenesulfonyl-3-butylurea
  • Aglicid
  • arcosal
  • Arkozal
  • Artosin
  • Artozin
  • n-((butylamino)carbonyl)-4-methyl-benzenesulfonamid
  • n-(4-methylphenylsulfonyl)-n’-butylurea
  • N-(4-Methylphenylsulfonyl)-N'-butylurea
  • N-(n-Butyl)-N'-p-toluene-sulfonylurea
  • N-(p-Methylbenzenesulfonyl)-N'-butylurea
  • n-(p-tolylsulfonyl)-n’-butylcarbamide
  • n-(p-tolylsulfonyl)n’-butylcarbamide
  • N-(p-Tolylsulfonyl)-N'-butylcarbamide
  • n-(sulfonyl-p-methylbenzene)-n’-butylurea
  • n-(sulfonyl-p-methylbenzene)-n’-n-butylurea
  • N-(Sulfonyl-p-methylbenzene)-N'-N-butylurea
  • n-[(butylamino)carbonyl]-4-methyl-benzenesulfonamid
  • inwardly rectifying subfamily J member 2
  • Anti-Kir5.1, C-Terminal antibody produced in rabbit
  • Inward rectifier K channel Kir5.1
  • IRK16
  • IRKG
  • KCNJ16
  • Anti-KCNJ5, C-Terminal antibody produced in rabbit
  • G protein-activated inward rectifier potassium channel 4
  • GIRK4
  • Inward rectifier K(+) channel Kir3.4
  • inwardly rectifying subfamily J member 5
  • Anti-KCNK1, C-Terminal antibody produced in rabbit
  • Inward rectifying potassium channel protein TWIK-1
  • Potassium channel KCNO1
  • Potassium channel subfamily K member 1
  • subfamily K
  • beglucin
  • Benzenesulfonamide, N-[(butylamino)carbonyl]-4-methyl-
  • Butamid
  • Butamide
  • BZ 55
  • D 860