Chlorpropamid Produkt Beschreibung

CHLORPROPAMIDE Struktur
94-20-2
  • CAS-Nr.94-20-2
  • Bezeichnung:Chlorpropamid
  • Englisch Name:CHLORPROPAMIDE
  • Synonyma:Chlorpropamid
    p607;P-607;u-9818;u-3818;Adiaben;Asucrol;Catanil;Glisema;Meldian;Oradian
  • CBNumber:CB8677954
  • Summenformel:C10H13ClN2O3S
  • Molgewicht:276.74
  • MOL-Datei:94-20-2.mol
Chlorpropamid physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :128 °C
  • Siedepunkt: :302°C (rough estimate)
  • Dichte :1.3046 (rough estimate)
  • Brechungsindex :1.6300 (estimate)
  • Aggregatzustand :neat
  • pka :pKa 4.8 (Uncertain)
  • Wasserlöslichkeit :Soluble in ethanol (1:12), acetone (1:5), chloroform (1:9) and solutions of alkali hydroxides. Does not mix well with water.
  • Merck  :14,2186
  • Stabilität: :Stable. Combustible.
  • CAS Datenbank :94-20-2(CAS DataBase Reference)
  • EPA chemische Informationen :Chloropropamide (94-20-2)
Sicherheit
  • Kennzeichnung gefährlicher :Xn
  • R-Sätze: :20/21/22-40
  • S-Sätze: :22-36
  • WGK Germany  :3
  • RTECS-Nr. :YS6650000
  • HS Code  :29350090
  • Toxizität :LD50 i.p. in rats: 580 mg/kg (Goldenthal)

CHLORPROPAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
    R40:Verdacht auf krebserzeugende Wirkung.
  • S-Sätze Betriebsanweisung: S22:Staub nicht einatmen.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Chemische Eigenschaften white crystalline powder
  • Verwenden Chlorpropamide is a sulfonylurea derivative. Chlorpropamide is a long acting hyopglycemic agent. Chlorpropamide is used in the treatment of diabetes metilus type 2. Chlorpropamide acts to increase the secretion of insulin and is not effective in patients who do not have pancreatic beta cell function.
  • Verwenden antidiabetic
  • Verwenden For treatment of NIDDM in conjunction with diet and exercise.
  • Definition ChEBI: An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypogly aemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
  • Trademarks Diabinese (Pfizer); Glucamide (Teva).
  • Allgemeine Beschreibung Chlorpropamide is 4-chloro-N-[(propylamino)carbonyl]benzenesulfonamide; or 1-[(p-chlorophenyl)sulfonyl]-3-propylurea; or 1-(p-chlorobenzenesulfonyl)-3-propylurea(Diabinese, generic). The p-chlorophenyl moiety is quite resistantto P450-mediated hydroxylations; hence, blood levelsof the drug are sustained for a markedly long length of time,as aliphatic hydroxylation constitutes most of the clearance,and this happens relatively slowly. Although the -hydroxyland (ω–1)-hydroxyl metabolites (the latter formed in muchgreater portion) exert hypoglycemic potencies not much lessthan does the parent drug, elimination of these by conversion to the corresponding glucuronides occurs more rapidly thanhydroxylation of chlorpropamide, so blood levels of thesemetabolites remain low, and thus they probably do not makean appreciable contribution to the hypoglycemic action ofthis drug in clinical application. Removal of the entire propylside chain (oxidative N-dealkylation) also occurs to a significantextent (up to 20% of an orally administered dose), creatingthe inactive metabolite p-chlorobenzenesulfonylurea,about 10% of which degrades to the corresponding benzenesulfonamide.
  • Allgemeine Beschreibung Chlorpropamide, 1-[(p-chlorophenyl)-sulfonyl]-3-propylurea (Diabinese), is a white, crys-talline powder, practically insoluble in water, soluble in alcohol,and sparingly soluble in chloroform. It will form watersolublesalts in basic solutions. This drug is more resistant toconversion to inactive metabolites than is tolbutamide and, asa result, has a much longer duration of action. One studyshowed that about half of the drug is excreted as metabolites,with the principal one being hydroxylated in the 2-position ofthe propyl side chain.After control of the blood sugar level,the maintenance dose is usually on a once-a-day schedule.
  • Allgemeine Beschreibung White crystalline powder with a slight odor.
  • Air & Water Reaktionen Insoluble in water.
  • Reaktivität anzeigen A halogenated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
  • Brandgefahr Flash point data for CHLORPROPAMIDE are not available; however, CHLORPROPAMIDE is probably combustible.
  • Veterinary Drugs and Treatments While chlorpropamide could potentially be of benefit in the adjunctive treatment of diabetes mellitus in small animals, its use has been primarily for adjunctive therapy in diabetes insipidus in dogs and cats.
  • läuterung methode Crystallise the urea from aqueous EtOH. [Beilstein 11 IV 119.]
CHLORPROPAMIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Chlorpropamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global(143)Suppliers
  • Firmenname:career henan chemical co
  • Telefon:+86-371-86658258
  • Fax:
  • E-Mail:sales@coreychem.com
  • Land:CHINA
  • Produktkatalog:30057
  • Edge Rate:58
  • Firmenname:Chemwill Asia Co.,Ltd.
  • Telefon:86-21-51086038
  • Fax:86-21-51861608
  • E-Mail:chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com
  • Land:CHINA
  • Produktkatalog:23978
  • Edge Rate:58
  • Firmenname:Hubei xin bonus chemical co. LTD
  • Telefon:86-13657291602
  • Fax:027-59338440
  • E-Mail:sales@guangaobio.com
  • Land:CHINA
  • Produktkatalog:23048
  • Edge Rate:58
  • Firmenname:Chongqing Chemdad Co., Ltd
  • Telefon:+86-13650506873
  • Fax:
  • E-Mail:sales@chemdad.com
  • Land:CHINA
  • Produktkatalog:35438
  • Edge Rate:58
  • Firmenname:CONIER CHEM AND PHARMA LIMITED
  • Telefon:86-18523575427
  • Fax:
  • E-Mail:sales@conier.com
  • Land:CHINA
  • Produktkatalog:47484
  • Edge Rate:58
  • Firmenname:Shenzhen Sendi Biotechnology Co.Ltd.
  • Telefon:0755-23311925 18102838259
  • Fax:0755-23311925
  • E-Mail:Abel@chembj.com
  • Land:CHINA
  • Produktkatalog:3194
  • Edge Rate:55
  • Firmenname:Mainchem Co., Ltd.
  • Telefon:+86-0592-6210733
  • Fax:+86-0592-6210733
  • E-Mail:sale@mainchem.com
  • Land:CHINA
  • Produktkatalog:32445
  • Edge Rate:55
  • Firmenname:J & K SCIENTIFIC LTD.
  • Telefon:400-666-7788 010-82848833-
  • Fax:86-10-82849933
  • E-Mail:jkinfo@jkchemical.com;market6@jkchemical.com
  • Land:China
  • Produktkatalog:96815
  • Edge Rate:76
  • Firmenname:TCI (Shanghai) Development Co., Ltd.
  • Telefon:021-67121386 / 800-988-0390
  • Fax:021-67121385
  • E-Mail:Sales-CN@TCIchemicals.com
  • Land:China
  • Produktkatalog:24555
  • Edge Rate:81
  • Firmenname:Energy Chemical
  • Telefon:021-58432009 / 400-005-6266
  • Fax:021-58436166-800
  • E-Mail:info@energy-chemical.com
  • Land:China
  • Produktkatalog:44026
  • Edge Rate:61
94-20-2, CHLORPROPAMIDE Verwandte Suche:
  • Chloropropamide USP
  • CHLORPROPAMIDE USP
  • 1-(p-chlorobenzenesulfonyl)-3-propylure
  • CHLORPROPRAMIDE
  • 4-chloro-N-(propylcarbamoyl)benzenesulfonamide
  • Chlorpropamide (200 mg)
  • ChlorproMaMide
  • 1-(4-Chlorophenylsulfonyl)-3-propylurea , 99.0%(T)
  • CHLOROPROPAMIDE
  • CHLORPROPAMIDE
  • 1-(4-CHLOROPHENYLSULFONYL)-3-PROPYLUREA
  • 1-[P-CHLOROBENZENESULFONYL]-3-PROPYLUREA
  • 1-((p-chloropenyl)sulfonyl)-3-propyl-ure
  • 1-((p-chlorophenyl)sulfonyl)-3-propyl-ure
  • 1-(p-Chlorophenylsulfonyl)-3-propylurea
  • 1-Chloro-4-(([(propylamino)carbonyl]amino)sulfonyl)benzene
  • 1-p-Chlorophenyl-3-(propylsulfonyl)urea
  • 1-Propyl-3-(p-chlorobenzenesulfonyl)urea
  • 4-Chloro-4-((propylamino)carbonyl)benzenesulfonamide
  • 4-chloro-n-((propylamino)carbonyl)-benzenesulfonamid
  • 4-chloro-n-[(propylamino)carbonyl]-benzenesulfonamid
  • 4-chloro-n-[(propylamino)carbonyl]benzenesulfonamide
  • 4-Chloro-N-[(propylamino)-carbonyl]benzenesulfonamide
  • 4-Chloro-N-[(propylamino)carbonyl]benzene-sul-fonamide
  • Adiaben
  • Asucrol
  • Benzenesulfonamide, 4-chloro-N-[(propylamino)carbonyl]-
  • bioglumin
  • Catanil
  • Chlorodiabina
  • Chloronase
  • Chlorpropamid
  • Clorpropamide
  • Diabaril
  • Diabechlor
  • Diabenal
  • Diabenese
  • Diabeneza
  • Diabetoral
  • Diabet-pages
  • diabexan
  • Diabinese
  • Diamel Ex
  • Dynalase
  • Glisema
  • Hexathane
  • Insulase
  • Meldian
  • Melitase
  • Mellinese
  • Millinese
  • n-(4-chlorophenylsulfonyl)-n’-propylurea
  • N-(4-Chlorophenylsulfonyl)-N'-propylurea
  • u-9818
  • Urea, 1-[(p-chlorophenyl)sulfonyl]-3-propyl-
  • n-(p-chlorobenzenesulfonyl)-n’-propylurea
  • N-(p-Chlorobenzenesulfonyl)-N'-propylurea
  • NCI-C01752