(+/-)1-(1-Naphthyl)ethylamine

Bezeichnung:(+/-)1-(1-Naphthyl)ethylamine

CAS-Nr42882-31-5

Englisch Name:(+/-)1-(1-Naphthyl)ethylamine

CBNumberCB4700526

SummenformelC12H13N

Molgewicht171.24

MOL-Datei42882-31-5.mol

(+/-)1-(1-Naphthyl)ethylamine physikalisch-chemischer Eigenschaften

Siedepunkt	156 °C15 mm Hg(lit.)
Dichte	1.063 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.621(lit.)
Flammpunkt	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	soluble in alcohol, ether; insoluble in H2O
pka	9.26±0.40(Predicted)
Aggregatzustand	clear liquid
Farbe	Colorless to Yellow to Green
Optische Rotation	Consistent with structure
Sensitive	Air Sensitive
BRN	3197375
InChI	InChI=1S/C12H13N/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11/h2-9H,13H2,1H3
InChIKey	RTCUCQWIICFPOD-UHFFFAOYSA-N
SMILES	C12C=CC=CC1=CC=CC=2C(N)C
CAS Datenbank	42882-31-5(CAS DataBase Reference)
EPA chemische Informationen	1-Naphthalenemethanamine, .alpha.-methyl- (42882-31-5)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38-34-25
S-Sätze:	26-36-45-36/37/39
RIDADR	2735
WGK Germany	3
F	10-34
TSCA	TSCA listed
HazardClass	8
PackingGroup	III
HS Code	29214990
Speicherklasse	10 - Combustible liquids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

(+/-)1-(1-Naphthyl)ethylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R34:Verursacht Verätzungen.
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Colorless or yellow liquidcrystalline
Verwenden
1-(1-Naphthyl)ethylamine is used in the enzymic resolution of amines. A chirality modifier.
Allgemeine Beschreibung
The adsorption of 1-(1-naphthyl)ethylamine on platinum surfaces has been characterized by reflection-absorption infrared spectroscopy and temperature-programmed desorption both under ultrahigh vacuum and in situ from liquid solutions.
Synthese

941-98-0

42882-31-5

General procedure for the synthesis of 1-naphthylethylamine from 1-naphthylethanone: The corresponding ketone (10 mmol, specifically 1.14 g of 1a, 0.98 g of 1b, 1.48 g of 1c, 1.46 g of 1d, 1.46 g of 1e, 1.32 g of 1f, 1.20 g of 1g, 1.70 g of 1h, 1.70 g of 1i) was mixed with hydroxylamine hydrochloride ( 15 mmol, 1.04 g), ammonium formate (60 mmol, 3.78 g) and zinc powder (30 mmol, 1.96 g) in methanol (30 mL) and the reaction was stirred under reflux conditions. After completion of the reaction, the reaction mixture was filtered through Celite. The filtrate was subjected to vacuum rotary evaporation to remove the solvent. The residue was treated with concentrated hydrochloric acid followed by the addition of 4 mL of HCl solution and 30 mL of water and extracted with ether (2 x 20 mL) to remove organic impurities. The aqueous phase was adjusted to pH=10 with ammonia and extracted with dichloromethane (4 x 25 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate, and finally the solvent was removed in vacuum to obtain the target product 1-naphthylethylamine.
Einzelnachweise
[1] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1310 - 1312
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 21, p. 6197 - 6208
[3] Patent: WO2008/58235, 2008, A2. Location in patent: Page/Page column 23-24
[4] Synthetic Communications, 2011, vol. 41, # 3, p. 341 - 346
[5] Molecules, 2014, vol. 19, # 12, p. 21386 - 21397

(+/-)1-(1-Naphthyl)ethylamine Upstream-Materialien And Downstream Produkte

(+/-)1-(1-Naphthyl)ethylamine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

42882-31-5, (+/-)1-(1-Naphthyl)ethylamine Verwandte Suche:

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