Fmoc-Gly-OH

Bezeichnung:Fmoc-Gly-OH

CAS-Nr29022-11-5

Englisch Name:Fmoc-Gly-OH

CBNumberCB4288480

SummenformelC17H15NO4

Molgewicht297.31

MOL-Datei29022-11-5.mol

Fmoc-Gly-OH physikalisch-chemischer Eigenschaften

Schmelzpunkt	174-175 °C(lit.)
Siedepunkt	438.82°C (rough estimate)
Dichte	1.1671 (rough estimate)
Brechungsindex	1.4500 (estimate)
storage temp.	2-8°C
Löslichkeit	almost transparency in Methanol
pka	3.89±0.10(Predicted)
Aggregatzustand	Powder
Farbe	White
BRN	2163967
InChI	InChI=1S/C17H15NO4/c19-16(20)9-18-17(21)22-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15H,9-10H2,(H,18,21)(H,19,20)
InChIKey	NDKDFTQNXLHCGO-UHFFFAOYSA-N
SMILES	C(O)(=O)CNC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS Datenbank	29022-11-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	24/25-36-26
WGK Germany	3
HS Code	29242995

Gefahreninformationscode (GHS)

Fmoc-Gly-OH Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to light yellow crystal powde
Verwenden
Fmoc-Gly-OH is an N-Fmoc-protected form of Glycine (G615990). Glycine is a nonessential amino acid that acts as an inhibitory neyrotransmitter in the vertebrate central nervous system. Glycine also posesses cytoprotective against oxidant damage in the kidney.
synthetische
Glycine (Gly) (0.5 g, 6.66 mmol) was dissolved in 10% NaCO₃ (14 ml) under stirring in a 50-ml flask. To the resulting solution, which had been put into an ice bath, 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) (1.72 g, 6.66 mmol) in dioxane (12 ml) was gradually added. The reaction mixture was stirred at room temperature for 4 hours. Then added water (150 ml) to the mixture. The aqueous phase layer was separated from the reaction mixture and stripped with ether three times (75 ml×3). The stripped aqueous layer was acidified with 2N HCl aqueous solution to a pH=2, followed by extraction with ethyl acetate three times (75 ml×3). The organic phase layer was recovered and concentrated to obtain crude product of 1.70 g. The crude product was recrystallized in a mixed solvent of ethyl acetate hexane=1:2 (30 ml), and white solid denoted as Fmoc-Gly-OH was obtained after filtration at a reduced pressure.
Allgemeine Beschreibung
The product number for this product was previously 04-12-1001.

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Fmoc-Gly-OH Upstream-Materialien And Downstream Produkte

Fmoc-Gly-OH Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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