6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin

Bezeichnung:6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin

CAS-Nr54-95-5

Englisch Name:Pentetrazol

CBNumberCB4248615

SummenformelC6H10N4

Molgewicht138.17

MOL-Datei54-95-5.mol

Synonyma

Pentetrazol

6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin

6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin physikalisch-chemischer Eigenschaften

Schmelzpunkt	59-61 °C (lit.)
Siedepunkt	194 °C/12 mmHg (lit.)
Dichte	1.0617 (rough estimate)
Brechungsindex	1.4910 (estimate)
Flammpunkt	194°C/12mm
storage temp.	-20°C
Löslichkeit	≥15.38 mg/mL in EtOH; ≥6.3 mg/mL in DMSO; ≥83.2 mg/mL in H2O
Aggregatzustand	solid
pka	1.25±0.20(Predicted)
Farbe	White, crystalline powder
Sensitive	Hygroscopic
Merck	14,7141
BRN	135492
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	CWRVKFFCRWGWCS-UHFFFAOYSA-N
CAS Datenbank	54-95-5(CAS DataBase Reference)
NIST chemische Informationen	Pentylenetetrazol(54-95-5)
EPA chemische Informationen	Pentetrazol (54-95-5)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-36/37/38-23/24/25
S-Sätze:	26-36/37/39-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	XF8225000
TSCA	Yes
HazardClass	6.1
PackingGroup	II
Toxizität	LD50 in rats (mg/kg): 85±2 s.c., 62 i.p. (Goldenthal)

Gefahreninformationscode (GHS)

Pentetrazol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABA_A receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABA_A receptor.
Chemische Eigenschaften
white crystalline powder
Originator
Pentylenetetrazole,Spectrum Chemicals and
Verwenden
Non-specific CNS stimulant; convulsant; narcotic antagonist.
Verwenden
Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.
Verwenden
analeptic, circulation stimulant
Definition
ChEBI: An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other espiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Manufacturing Process
A solution of 9.8 g cyclohexanone and 8.6 g HNO3 in about 250 ml benzene were slowly added dropwise to 20 ml concentrate sulfuric acid in 100 ml benzene by ice cooling and stirring. After ending of a generation of N2 (0.1 moles) to a corresponding quantity of cyclohexane (0.1 moles). Acid layer was diluted with ice, and made neutral with strong alkaline to give a reaction product as oil. Then it was exrtacted with chloroform, all solvents were distilled and the residue was diluted with water. The desired 6,7,8,9tetrahydro-5H-tetrazoloazepine dropped. Yield was 7.5 g after recrystallization from ester or distillation. M.P: 65°C.
Trademarks
Cardiazol (Knoll).
Therapeutic Function
Analeptic, Central stimulant
Allgemeine Beschreibung
White crystalline powder or granular solid with a slightly pungent odor. Bitter taste. Aqueous solutions neutral to litmus.
Air & Water Reaktionen
Dust can be explosive when suspended in air at specific concentrations. Water soluble.
Reaktivität anzeigen
Pentetrazol is incompatible with oxidizing agents. . Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Azo dyes can be explosive when suspended in air at specific concentrations.
Brandgefahr
Flash point data for Pentetrazol are not available. Pentetrazol is probably combustible.
Biologische Aktivität
CNS stimulant that induces kindling in vivo . Causes alterations in excitatory and inhibitory neurotransmitter systems.
Biochem/physiol Actions
Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.
Sicherheitsprofil
A human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intravenous, intraperitoneal, subcutaneous, rectal, and parenteral routes. When heated to decomposition it emits toxic fumes of NOx.
Lager
-20°C
läuterung methode
pKEst Crystallise metrazol from diethyl ether and dry it under vacuum over P2O5, or distil it. [Schmidt Chem Ber 57 704 1924, Beilstein 26 II 213.]

Pentetrazol Upstream-Materialien And Downstream Produkte

6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

54-95-5, Pentetrazol Verwandte Suche:

Send Inquriy