1H-Tetrazol

Bezeichnung:1H-Tetrazol

CAS-Nr288-94-8

Englisch Name:Tetrazole

CBNumberCB4230898

SummenformelCH2N4

Molgewicht70.05

MOL-Datei288-94-8.mol

Synonyma

1H-Tetrazol

1H-Tetrazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	156-158°C
Siedepunkt	220℃
Dichte	0.798 g/mL at 20 °C
Brechungsindex	n20/D 1.348
RTECS-Nr.	UW7370000
Flammpunkt	5 °C
storage temp.	Room temperature.
Löslichkeit	DMSO, Methanol
Aggregatzustand	Liquid
pka	4.9(at 25℃)
Farbe	Cream to orange
Wasserlöslichkeit	Soluble
Decomposition	220°C
BRN	105799
Stabilität	Stable at RT
InChIKey	KJUGUADJHNHALS-UHFFFAOYSA-N
CAS Datenbank	288-94-8(CAS DataBase Reference)
NIST chemische Informationen	1H-Tetrazole(288-94-8)
EPA chemische Informationen	1H-Tetrazole (288-94-8)

Sicherheit

Kennzeichnung gefährlicher	F,Xn,E
R-Sätze:	11-20/21/22-36-5-4
S-Sätze:	16-26-36-36/37-35-15
RIDADR	UN 1993 3/PG 2
WGK Germany	3
F	3-4.15-10
HazardClass	4.1
PackingGroup	III
HS Code	29339900

Gefahreninformationscode (GHS)

Tetrazole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36:Reizt die Augen.
R5:Beim Erwärmen explosionsfähig.
R4:Bildet hochempfindliche explosionsgefährliche Metallverbindungen.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white crystals or crystalline powder
Verwenden
Tetrazole is a catalyst for phosphoramidite synthesis. It is also used as an intermediate for the drug cilostazol. Cilostazol is an antiplatelet drug and a vasodilator. Tetrazole derivatives are used as antibiotics and optically active tetrazole-containing antifungal preparations of azole type was reported.
synthetische
The first tetrazole synthesis was reported in 1885.
Tetrazole Synthesis: Nano-TiCl4.SiO2 (0.1 g) was added to a mixture of benzonitrile (1 mmol), sodium azide (2 mmol) in DMF (5 mL) at reflux for 2 h. After completion of reaction (as monitored by TLC), the mixture was allowed to cool to room temperature, the catalyst was removed by filtration. Then by adding ice water and 4N HCl (5 mL) to the residue, a white solid was obtained. This was then washed with cold chloroform. This simple procedure yielded pure tetrazole with good yields.
Definition
ChEBI: 1H-tetrazole is a tetrazole tautomer where the proton is located on the 1st position. It is a tetrazole and a one-carbon compound. It is a tautomer of a 2H-tetrazole and a 5H-tetrazole.
Application
1H-Tetrazole is used as a bioisostere for the carboxylate group. It is also used as coupling reagent for preparation of polynucleotides.
Allgemeine Beschreibung
Tetrazole is an odorless white to light-yellow crystalline powder. Mp:1 55-157°C. When heated to decomposition Tetrazole emits toxic oxides of nitrogen fumes. Can explode if exposed to shock or heat from friction or fire. The primary hazard is from blast effect where the entire load can explode instantaneously and not from flying projectiles and fragments.
Health Hazard
Fire may produce irritating, corrosive and/or toxic gases.
Brandgefahr
MAY EXPLODE AND THROW FRAGMENTS 1600 meters (1 MILE) OR MORE IF FIRE REACHES CARGO.
läuterung methode
Crystallise the tetrazole from EtOH and sublime it under high vacuum at ca 120o (care should be taken due to possible EXPLOSION). [Beilstein 26 H 346, 26 I 108, 26 II 196, 26 III/IV 1652.]

Tetrazole Upstream-Materialien And Downstream Produkte

1H-Tetrazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

288-94-8, Tetrazole Verwandte Suche:

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