Epirizol

Bezeichnung:Epirizol

CAS-Nr18694-40-1

Englisch Name:Epirizole

CBNumberCB4154565

SummenformelC11H14N4O2

Molgewicht234.25

MOL-Datei18694-40-1.mol

Synonyma

Epirizol

Epirizol physikalisch-chemischer Eigenschaften

Schmelzpunkt	90-92°
Siedepunkt	376.57°C (rough estimate)
Dichte	1.1972 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	0.65±0.50(Predicted)
Farbe	White to off-white
CAS Datenbank	18694-40-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	UV9290000
Toxizität	LD50 orally in mice: 820 mg/kg (Ogura)

Gefahreninformationscode (GHS)

Epirizole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Originator
Mebron,Daiichi Seiyaku,Japan,1970
Verwenden
Analgesic; anti-inflammatory.
Verwenden
Mepirizole induces precocious differentiation of insulin-producing ti-cells in larval zebrafish. Also, it increases the expression of MDR1 mRNA in Caco-2 cells; Non-acidic analgesic.
Definition
ChEBI: Epirizole is an aromatic ether.
Manufacturing Process
A mixture of 16.3 g of 4-methyl-6-methoxy-2-pyrimidinyl-hydrazine,13.7 g of ethyl acetoacetate and 16.3 ml of methanol was refluxed 2 hours on a water bath. After a mixture of 4.7 g of sodium hydroxide, 4.7 ml of water and 27 ml of methanol was added dropwise thereto at about 50°C, the reaction mixture was refluxed for 2 hours more, then methanol was distilled off and the residue was dissolved in 130 ml of water. The solution was adjusted to pH 6 with acetic acid. The precipitate was filtered, washed with water and dried to give 24 g (yield: 95.3%) of crystals, MP 97° to 98°C. Recrystallization from ligroin gave 1-(4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl-3-pyrazoline-5-one, MP 102° to 103°C.
To a solution of 4.76 g of 1-( 4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl- 3-pyrazoline 5-one in 200 ml of ether was added an ether solution containing 6 molar equivalents of diazomethane and the reaction mixture was allowed to stand at room temperature for 20 hours. After distilling off the solvent, the residue was dissolved in 160 ml of water, made alkaline (pH 10) with sodium hydroxide solution and extracted three times with 140 ml of benzene. The extract was washed with a small amount of water, dried over sodium sulfate and evaporated to give a crystalline mass. Recrystallization from isopropylether gave 1-(4'-methyl-6'-methoxy-2'-pyrimidinyl)-3-methyl-5- methoxypyrazole (3.96 g, 84%) as color less prisms, MP 90° to 92°C.
Therapeutic Function
Antiinflammatory, Analgesic, Antipyretic

Epirizole Upstream-Materialien And Downstream Produkte

Epirizol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

18694-40-1, Epirizole Verwandte Suche:

Send Inquriy