Phenolphthalein

Bezeichnung:Phenolphthalein

CAS-Nr77-09-8

Englisch Name:Phenolphthalein

CBNumberCB4141228

SummenformelC20H14O4

Molgewicht318.32

MOL-Datei77-09-8.mol

Synonyma

Phenolphthalein

Phenolphthalein physikalisch-chemischer Eigenschaften

Schmelzpunkt	261-263 °C (lit.)
Siedepunkt	417.49°C (rough estimate)
Dichte	1.27 g/cm3 at 32 °C
Brechungsindex	1.5400 (estimate)
Flammpunkt	24 °C
storage temp.	no restrictions.
Löslichkeit	Soluble in alcohol. Slightly soluble in ether. Slightly soluble in dimethyl sulfoxide and insoluble in benzene or hexane.
Aggregatzustand	Solid
pka	9.4(at 25℃)
Colour Index	764
Farbe	White to yellow-white
Säure-Base-Indikators(pH-Indikatoren)	8.0(colorless)-10(Red)
PH	7.8～10.0
Geruch (Odor)	Odorless
Wasserlöslichkeit	<0.1 g/100 mL
maximale Wellenlänge (λmax)	552nm, 553nm, 374nm, 205nm, 229nm, 276nm
Merck	14,7243
BRN	284423
Stabilität	Stable. Incompatible with strong oxidizing agents, alkalies.
Major Application	Display device, sensors, semiconductors, fuel cells, photoreceptors, electronic packaging, authentication system for secure documents, inks, correction fluid, paints, detection of defects in films, floor coatings, textiles, corrosion testing, explosive, concrete, toys, detecting lipase activity of crop seeds, soaps, method for prevention of drugmisuse, cosmetics, diapers, detecting viable cells, carbohydrates, antimalarial, treating amyloid-associated diseases
LogP	2.410
CAS Datenbank	77-09-8(CAS DataBase Reference)
IARC	2B (Vol. 76) 2000
NIST chemische Informationen	Phenolphthalein(77-09-8)
EPA chemische Informationen	3,3-Bis(4-hydroxyphenyl)phthalide (77-09-8)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F,Xi
R-Sätze:	40-22-10-36/38-23/25-11-36/37/38-68-62-45-39/23/24/25-23/24/25
S-Sätze:	45-36/37-33-24-16-7-36-26-53
WGK Germany	3
RTECS-Nr.	SM8380000
TSCA	Yes
HS Code	29322910
Giftige Stoffe Daten	77-09-8(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Phenolphthalein Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
R22:Gesundheitsschädlich beim Verschlucken.
R10:Entzündlich.
R36/38:Reizt die Augen und die Haut.
R23/25:Giftig beim Einatmen und Verschlucken.
R11:Leichtentzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S33:Maßnahmen gegen elektrostatische Aufladungen treffen.
S24:Berührung mit der Haut vermeiden.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S7:Behälter dicht geschlossen halten.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to light yellow crystal powde
Verwenden
Phenolphthalein is one of those chemicals that is commonly used in the chemistry laboratory to tell if a solution is acidic or alkaline . These chemicals are called acid - base indicators and used as indicator for acidimetric titrations. Phenolphthalein exerts laxative effects by stimulating the intestinal mucosa and constricting smooth muscles. However, phenolphthalein is no longer used as a laxative due to the suspected carcinogenicity of this compound.
Verwenden
Phenolphthalein can be used as an inhibitor and pH indicator. It also induces centrosome amplification and tubulin depolymerization in vitro.
Definition
phenolphthalein: A dye used as anacid-base indicator. It is colourlessbelow pH 8 and red above pH 9.6. Itis used in titrations involving weakacids and strong bases. It is also usedas a laxative.
Definition
An acid–base indicator that is colorless in acid solutions and becomes red if the pH rises above the transition range of 8–9.6. It is used as the indicator in titrations for which the end point lies clearly on the basic side (pH>7), e.g. oxalic acid or potassium hydrogentartrate against caustic soda.
Trademarks
Evac-Q-Tabs (Savage); Ex-Lax (Novartis); Modane (Savage); Prulet (Mission Pharmacal);Agaffin;Alophen pills;Anodyne dellipsoids 4;Ap-la-day;Bold laxine;Bom-bon;Bon-bon;Canisan;Certolax;D & m tablets;Darmol;Euchessinia;Evac-qwik tablets;Evactil;Feen-a-mint;Fractines vichy;Fractine-vichy;Fructines-vichy;Kalimalterin;Kest;Kondremul with phenolphtalein;Laxante yer;Laxatabs;Laxatone;Laxen busto;Minilax;Modane plus;Mucinum;Musilaks;Neoprunex;Neopurghes;Novopuren;Paradeines;Peplax;Petrolaglar emulsion;Petro-mul-phen;Phillips laxcaps;Prifunal;Prunetta;Pugrante el aleman;Purganol;Purganos-daguin;Purgant aleman;Purgante orravan;Purgenum;Purgestol;Purgoids;Purgyl;Purjen sahap;Sarolax;Thalinol mrt;Unisvelt;Veracolate.
Weltgesundheitsorganisation (WHO)
Phenolphthalein has been widely used as a laxative since its cathartic activity was first described in 1902. Because it undergoes enterohepatic circulation it is eliminated slowly and it has been associated with adverse effects, notably skin reactions, potassium loss and atonia. This has led to the withdrawal of phenolphthalein from pharmaceutical preparations in several countries. Elsewhere, it remains available, often in over-the-counter preparations.
Allgemeine Beschreibung
Phenolphthalein solution is a synthetic indicator. It is colorless in acidic and neutral conditions. Phenolphthalein gives pink color when added to a base, therefore it is considered as a base indicator.
Sicherheitsprofil
Confirmed carcinogen. US Food and Drug Administration recommends removal from laxative formulations. Moderately toxic by intraperitoneal route. Human systemic effects: changes in urine composition, gastritis, nausea or vomiting. Used in medicine as a laxative; in chemistry as an indicator. When heated to decomposition it emits acrid smoke and irritating fumes
Carcinogenicity
Phenolphthalein is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
läuterung methode
Dissolve it in EtOH (7mL/g), then dilute it with eight volumes of cold water, filter and heat on a water-bath to remove most of the alcohol and the phenolphthalein that precipitates is filtered off and dried in vacuo.[Beilstein 18 II 119, 18 III/1V 1945, 18/4 V 188.]

Phenolphthalein Upstream-Materialien And Downstream Produkte

Phenolphthalein Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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