licarin B

licarin B Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from nutmeg, Lauraceae (Lauraceae) Licarin aritu Ducke trunk (yield: 0.35%) Machilus japonica Sieb.et Zucc. Ye Hongnan Machilus thunbergii Sieb.et Zucc. Bark, wood, leaves.

• Verwenden

  Licarin B has antibacterial, anti-inflammatory, sedative and anti-tumor effects.

• Biologische Aktivität

  Licarin B, derived from the seeds of Myristica fragrans, is an inhibitor of NO production and improves insulin sensitivity by activating PPARγ and GLUT4 in the IRS-1/PI3K/AKT pathway.

• in vitro

  Licarin B (5 μM, 10 μM, 15 μM. 8 days) moderately increases TG accumulation during adipogenic differentiation and showed partial PPARg agonist activity in 3T3-L1 preadipocytes.

  Cell Viability Assay < /p>

  Cell Line:	3T3-L1 cell.
  Concentration:	1-500 μM.
  Incubation Time:	48 h.
  Result:	Did not cause significant cell death up to 500 μM concentration.

  Cell Viability Assay

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  Cell Line:	3T3-L1 cell.
  Concentration:	5 μM, 10 μM, 15 μM.
  Incubation Time:	8 days (replaced every 2 days).	8 days (replaced every 2 days).
  Result:	LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation.

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• target

  PPAR | GLUT | PI3K | Akt | IRS-1

licarin B Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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