Stigmast-5-en-3-β-ol

Bezeichnung:Stigmast-5-en-3-β-ol

CAS-Nr83-46-5

Englisch Name:beta-Sitosterol

CBNumberCB4345688

SummenformelC29H50O

Molgewicht414.72

MOL-Datei83-46-5.mol

Synonyma

Stigmast-5-en-3-β-ol

Stigmast-5-en-3-β-ol physikalisch-chemischer Eigenschaften

Schmelzpunkt	136-140 °C(lit.)
alpha	-28 º (c=2, CHCl3)
Siedepunkt	473.52°C (rough estimate)
Dichte	0.9540 (rough estimate)
Brechungsindex	1.5000 (estimate)
storage temp.	2-8°C
Löslichkeit	chloroform: 20 mg/mL, clear, colorless
pka	15.03±0.70(Predicted)
Aggregatzustand	White solid
Farbe	White to Off-White
Optische Aktivität	-3725 (c 2, CHCl3)
Wasserlöslichkeit	INSOLUBLE
Merck	14,8556
BRN	1916165
InChIKey	KZJWDPNRJALLNS-VJSFXXLFSA-N
LogP	10.482 (est)
CAS Datenbank	83-46-5(CAS DataBase Reference)
NIST chemische Informationen	«beta»-Sitosterol(83-46-5)
EPA chemische Informationen	.beta.-Sitosterol (83-46-5)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-38-40-48/20/22-36/37/38-67-36/38-20-63
S-Sätze:	22-24/25-36-26-36/37
RIDADR	UN 1888 6.1/PG 3
WGK Germany	3
RTECS-Nr.	WJ2600000
F	10
HS Code	29061990

Gefahreninformationscode (GHS)

beta-Sitosterol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R38:Reizt die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R48/20/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen und durch Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
24α-ethyl Cholesterol is a naturally occurring plant sterol with antioxidant, anticancer, anti-inflammatory, angiogenic, chemopreventive, and immunomodulatory activities. It inhibits the absorption of dietary and endogenously-produced cholesterol from the small intestine, reducing blood cholesterol concentrations. Because of its nutraceutical benefits, 24α-ethyl cholesterol has been used as a food additive intended to lower LDL cholesterol. 24α-ethyl Cholesterol (0.1 - 100 μM) can dose-dependently induce adipogenesis and lipolysis in rat primary preadipocytes as well as stimulate glucose uptake in differentiated adipocytes.
Chemische Eigenschaften
White powder
Verwenden
A common sterol in plants. Isolated from wheat germ oil, corn oil. Antilipemic. Used in the treatment of prostatic adenoma.This compound is a contaminant of emerging concern (CECs)
Verwenden
antiinflammatory, immunomodulator
Definition
ChEBI: A phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.
Definition
sterol: Any of a group of steroidbasedalcohols having a hydrocarbonside-chain of 8–10 carbon atoms.Sterols exist either as free sterols oras esters of fatty acids. Animal sterols(zoosterols) include cholesterol andlanosterol. The major plant sterol(phytosterol) is beta-sitosterol, whilefungal sterols (mycosterols) includeergosterol.
Definition
A steroid with long aliphatic side chains (8–10 carbons) and at least one hydroxyl group. They are lipidsoluble and often occur in membranes. Examples are cholesterol and ergosterol.
Allgemeine Beschreibung
Sitosterol, also called as β-sitosterol, is synthesized through the mevalonate and deoxy xylulose pathways. Synthetically, it is synthesized from stigmasterol by Δ22–23 alkene group hydrogenation. Structurally sitosterol differ from cholesterol with ethyl (sitosterol) group in C24 position of side chain(65). Sitosterol is a lipid component of membranes. It corresponds to a molecular mass of 414.71 g/mol).
Biochem/physiol Actions
Sitosterol promotes the antioxidant levels and is used as an effective anti-inflammatory, antiapoptotic and anticancer agent in medicinal preparations. It acts as a neutralizing agent for the venom from viper and cobra. Sitosterol acts on protein kinase C (PKC) and in the sphingomyelin cycle to mediate tumor progression inhibition.
läuterung methode
Crystallise -sitosterol from EtOH, MeOH, Me2CO, Me2CO/EtOH or Me2CO/MeOH. It has also been purified by zone melting. The acetate crystallises from MeOH or EtOH as plates with m 127128o and [] D 20 -41o (c 2, CHCl3). The benzoate crystallises from EtOH as needles with m 146-147o and [] D 20 –13.8o (c 2, CHCl3). [Fujimoto & Jacobson J Org Chem 29 3377, 3381 1964, Shoppee J Chem Soc 10431948, Heilbron et al. J Chem Soc 344, 347 1941, Beilstein 6 III 2696.]

beta-Sitosterol Upstream-Materialien And Downstream Produkte

Stigmast-5-en-3-β-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

83-46-5, beta-Sitosterol Verwandte Suche:

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