Mecamylamin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H312：Gesundheitsschädlich bei Hautkontakt.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H332：Gesundheitsschädlich bei Einatmen.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P312：Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P321：Besondere Behandlung

  P322：Gezielte Maßnahmen

  P330：Mund ausspülen.

  P332+P313：Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P362：Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

  P363：Kontaminierte Kleidung vor erneutem Tragen waschen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

methyl(2,3,3-trimethyltrinorbornan-2-yl)amine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Inversine ,MSD ,US ,1956

• Verwenden

  Antihypertensive.

• Definition

  ChEBI: Mecamylamine is a primary aliphatic amine.

• Manufacturing Process

  Preparation of 2-(N-Formylamino)Isocamphane: Into a 5-liter 3-necked round bottom flask equipped with stirrer, dropping funnel and thermometer, was added 325 ml of glacial acetic acid. Then, portionwise, a total of 133 g of sodium cyanide (granular, 2.6 mols) was added with stirring while holding the temperature at 15°C. To the thick white slurry was added dropwise a previously prepared cold mixture of 325 ml glacial acetic acid and 360 ml concentrated sulfuric acid.
  After addition of a few milliliters at 15°C, the thick slurry thins slowly and the remainder of the sulfuric-glacial acetic acid mixture was added at 0° to 2°C. A total of about 2 hours was required for the addition. After addition, stirring was continued for 15 minutes, Then dropwise, over an hour, a solution of 178 g (1.3 mold of dl-camphene in 50 ml of glacial acetic acid was added while keeping the temperature at about 0°C (±3°C).
  Stirring was continued for two hours at 0°C during which time a slight pinkish-yellow color developed in the reaction mixture. The cooling bath was removed and the temperature allowed to rise to 15° to 20°C in about 2 to 3 hours. The ice bath was then re placed and while holding the temperature at about 20°C, the mixture was gradually diluted with 3 liters of water while stirring vigorously. After an hour or two of good agitation at room temperature, the oily product was extracted with 2 x 500 ml and 1 x 200 ml of chloroform and the combined extracts washed with 2 x 500 ml of water. The chloroform extract was then rendered neutral by stirring with 500 ml water and gradually adding solid sodium bicarbonate to the mixture until the aqueous phase had a pH of about 7; required, approximately 88 g of NaHCO3.
  After separation the chloroform layer was washed with 2 x 500 ml water, dried over calcium chloride, and after filtration the solvent was removed in vacuo on the steam bath. A solid somewhat sticky residue of 231.2 g was obtained. After removal of last traces of chloroform by repeated swishing with petroleum ether, the cake was finally refluxed with about 500 ml petroleum ether (BP 30° to 60°C) until a thick crystalline slurry was obtained. After refrigeration for a day, the white crystalline mass was filtered by suction, washed with petroleum ether (2 x 125 ml), then n-heptane (2 x 125 ml) and again with petroleum ether (2 x 125 ml). After air drying at room temperature to constant weight, 180.6 g of the dl-2-(N-formylamino)isocamphane melting at 160° to 165°C was obtained.
  The combined petroleum ether and n-heptane washes were concentrated under diminished pressure and the residual oil dissolved in a minimum amount of hot petroleum ether (about 75 ml). The resulting solution was placed in the refrigerator for two days. The precipitated dl-2-(N-formylamino) isocamphane was then recovered by filtration and washed with petroleum ether and n-heptane as described above. Obtained, 12.6 g of product having a MP of 158° to 164°C.
  The dl-2-(N-formylamino)isocamphane (193 g) was dissolved in 1.9 liters nheptane by heating on a steam bath, After clarifying the solution by filtration, the clear filtrate was allowed to stand at room temperature until crystallization was complete. The crystalline product is filtered by suction, washed with a little cold n-heptane and air dried. The dl-2-(N-formylamino)isocamphane melted at 169° to 174°C.
  Preparation of 2-(N-Methylamino)Isocamphane: To 4.23 liters of anhydrous ether in a 12-liter 3-necked flask fitted with a stirrer, reflux condenser and dropping funnel was quickly added 78 g (2.05 mols) of lithium aluminum hydride. The mixture was gently refluxed with stirring until all hydride had dissolved which required several hours.
  A solution of 168 g (0.92 mol) of dl-2-(N-formylamino)isocamphane, prepared as described above, in 1.81 liters of anhydrous ether was then added during a period of about one hour with stirring. After addition, the mixture was refluxed for about 6 hour

• Therapeutic Function

  Antihypertensive

methyl(2,3,3-trimethyltrinorbornan-2-yl)amine Upstream-Materialien And Downstream Produkte

Mecamylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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