Cetirizine

Bezeichnung:Cetirizine

CAS-Nr83881-51-0

Englisch Name:Cetirizine

CBNumberCB3440625

SummenformelC21H25ClN2O3

Molgewicht388.89

MOL-Datei83881-51-0.mol

Cetirizine physikalisch-chemischer Eigenschaften

Schmelzpunkt	110-115°C
Siedepunkt	542.1±45.0 °C(Predicted)
Dichte	1.237±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	insoluble in EtOH; ≥122 mg/mL in H2O; ≥19.44 mg/mL in DMSO
Aggregatzustand	solid
pka	3.46±0.10(Predicted)
Wasserlöslichkeit	101 mg/L
CAS Datenbank	83881-51-0(CAS DataBase Reference)
EPA chemische Informationen	Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- (83881-51-0)

Sicherheit

WGK Germany	3
RTECS-Nr.	AG0977500
Giftige Stoffe Daten	83881-51-0(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Cetirizine Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
white, crystalline powder
Verwenden
Cetirizine is a metabolite of the first-generation H1 antihistamine hydroxyzine. A reduced dosage (5 mg daily) is recommended in patients with chronic renal or hepatic impairment. Sedative side effects increase with dosages of cetirizine >10 mg per day.
Definition
ChEBI: A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
Trademarks
Zyrtec (Pfizer).
Allgemeine Beschreibung
Cetirizine, (±)-[2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetic acid (Zyrtec), is a racemic compound available as a white crystalline powder that is water soluble. Cetirizine is the primary acid metabolite of hydroxyzine, resulting from complete oxidation of the primary alcohol moiety. This compound is zwitterionic and relatively polar and thus does not penetrate or accumulate in the CNS. Before its introduction in the United States, cetirizine was one of the most widely prescribed H1-antihistamines in Europe.
Cetirizine is indicated for the temporary relief of runny nose, sneezing, itching of the nose or throat, and/or itchy, watery eyes caused by hay fever or other upper respiratory allergies. It also relieves itching caused by hives (urticaria), but it will not prevent hives or an allergic skin reaction from occurring.
Biologische Aktivität
cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective h1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. it has also been shown to inhibit eosinophil chemotaxis and ltb4 release. at a dosage of 20 mg, boone et al. found that it inhibited the expression of vcam-1 in patients with atopic dermatitis. the levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. from wikipedia.
Clinical Use
Cetirizine, the acid metabolite from oxidation of the primary alcohol of the antihistamine hydroxyzine, is a widely used antihistamine. It has a long duration of action and is highly selective for H1 receptors. No cardiotoxicity has been reported, but some drowsiness occurs.

Cetirizine Upstream-Materialien And Downstream Produkte

Cetirizine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

83881-51-0, Cetirizine Verwandte Suche:

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