Hydroxyzindihydrochlorid

Bezeichnung:Hydroxyzindihydrochlorid

CAS-Nr2192-20-3

Englisch Name:Hydroxyzine dihydrochloride

CBNumberCB2777401

SummenformelC21H29Cl3N2O2

Molgewicht447.83

MOL-Datei2192-20-3.mol

Synonyma

Hydroxyzindihydrochlorid

Hydroxyzindihydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	190-192°C
Flammpunkt	9℃
storage temp.	2-8°C
Löslichkeit	H₂O: soluble
Aggregatzustand	powder
Farbe	White to Off-White
CAS Datenbank	2192-20-3(CAS DataBase Reference)
EPA chemische Informationen	Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride (2192-20-3)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26
WGK Germany	3
RTECS-Nr.	KK2280000
HS Code	29335990
Toxizität	LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal)

Gefahreninformationscode (GHS)

Hydroxyzine dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White Solid
Originator
Atarax,UCB,France,1956
Verwenden
Anti histamines
Verwenden
Antihistaminic;H1 antogonist
Verwenden
H1 receptor antagonist. Anxiolytic. Antihistaminic.
Verwenden
Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.
Manufacturing Process
A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous solution of NaOH; decanting takes place, and the benzene solution is washed with water and the solvent is evaporated. Vacuum distilling of the residue yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP 220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about twice its weight of alcohol, by treating it with excess of gaseous HCl and by precipitating it with ether. The solvent is decanted and the residue, dissolved in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.
Trademarks
Amplimexon (Amplimed).
Therapeutic Function
Tranquilizer
Allgemeine Beschreibung
Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biochem/physiol Actions
Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

Hydroxyzine dihydrochloride Upstream-Materialien And Downstream Produkte

Hydroxyzindihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2192-20-3, Hydroxyzine dihydrochloride Verwandte Suche:

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