5-Bromo-2-fluorobenzaldehyde

Bezeichnung:5-Bromo-2-fluorobenzaldehyde

CAS-Nr93777-26-5

Englisch Name:5-Bromo-2-fluorobenzaldehyde

CBNumberCB3364493

SummenformelC7H4BrFO

Molgewicht203.01

MOL-Datei93777-26-5.mol

5-Bromo-2-fluorobenzaldehyde physikalisch-chemischer Eigenschaften

Schmelzpunkt	58-62°C
Siedepunkt	230 °C (lit.)
Dichte	1.71 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.57(lit.)
Flammpunkt	229 °F
storage temp.	2-8°C
Aggregatzustand	powder to lump to clear liquid
Farbe	White or Colorless to Light yellow
Wichte	1.710
Wasserlöslichkeit	INSOLUBLE
Sensitive	Air Sensitive
BRN	7632798
InChI	InChI=1S/C7H4BrFO/c8-6-1-2-7(9)5(3-6)4-10/h1-4H
InChIKey	MMFGGDVQLQQQRX-UHFFFAOYSA-N
SMILES	C(=O)C1=CC(Br)=CC=C1F
CAS Datenbank	93777-26-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29130000
Speicherklasse	10 - Combustible liquids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

5-Bromo-2-fluorobenzaldehyde Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
clear yellowish liquid after melting
Verwenden
5-Bromo-2-fluorobenzaldehyde is used for the preparation of benzimidazole derivatives as inhibitors of leukotriene production.
Synthese

446-52-6

93777-26-5

Example 3: In a reactor equipped with an electric stirrer, a thermometer, a dropping funnel and a condenser tube, 500 mL of aqueous sulfuric acid solution was added. Subsequently, a mixture of 167 g (1 mol) of potassium bromate and 124.1 g (1 mol) of 2-fluorobenzaldehyde was slowly added dropwise to the reaction system, the reaction temperature was maintained at 90°C, and the dropwise process continued for 2 to 3 hours. Upon completion of the reaction, 1000 mL of water was added to the system and extracted using methyl tert-butyl ether. The organic phase was subsequently washed with aqueous sodium sulfite and dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated to remove the methyl tert-butyl ether to give a brownish red oil. Finally, the 63-65°C/3 mmHg fraction was collected by vacuum distillation to afford 178 g of the target product 5-bromo-2-fluorobenzaldehyde in 88% yield and 97% purity.
Einzelnachweise
[1] Patent: CN105884591, 2016, A. Location in patent: Paragraph 0008; 0009; 0010; 0011

5-Bromo-2-fluorobenzaldehyde Upstream-Materialien And Downstream Produkte

5-Bromo-2-fluorobenzaldehyde Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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