1-Fluor-2,4-dinitrobenzol

Bezeichnung:1-Fluor-2,4-dinitrobenzol

CAS-Nr70-34-8

Englisch Name:2,4-Dinitrofluorobenzene

CBNumberCB9442373

SummenformelC6H3FN2O4

Molgewicht186.1

MOL-Datei70-34-8.mol

Synonyma

1-Fluor-2,4-dinitrobenzol

1-Fluor-2,4-dinitrobenzol physikalisch-chemischer Eigenschaften

Schmelzpunkt	25-27 °C (lit.)
Siedepunkt	178 °C/25 mmHg (lit.)
Dichte	1.482 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.569(lit.)
Flammpunkt	>230 °F
storage temp.	2-8°C
Löslichkeit	chloroform: 0.1 g/mL, clear
Aggregatzustand	Liquid or Low Melting Crystals
Farbe	Yellow to brownish
Wichte	1.482
Wasserlöslichkeit	400 mg/L (25 ºC)
Merck	14,4172
BRN	398632
Stabilität	Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS Datenbank	70-34-8(CAS DataBase Reference)
NIST chemische Informationen	Benzene, 1-fluoro-2,4-dinitro-(70-34-8)
EPA chemische Informationen	2,4-Dinitrofluorobenzene (70-34-8)

Sicherheit

Kennzeichnung gefährlicher	C,T,Xn
R-Sätze:	22-33-34-42/43-40-23/24/25-43-36/38-36/37/38
S-Sätze:	22-26-36/37/39-45-28A-23-7/9-36/37
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS-Nr.	CZ7800000
Hazard Note	Toxic
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29049085
Giftige Stoffe Daten	70-34-8(Hazardous Substances Data)

Gefahreninformationscode (GHS)

2,4-Dinitrofluorobenzene Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R33:Gefahr kumulativer Wirkungen.
R34:Verursacht Verätzungen.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R40:Verdacht auf krebserzeugende Wirkung.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R43:Sensibilisierung durch Hautkontakt möglich.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S7/9:Behälter dicht geschlossen an einem gut gelüfteten Ort aufbewahren.
Chemische Eigenschaften
Yellow solid
Verwenden
A substituted benzene use in polypeptide sequencing (also referred to as Sanger’s reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria.
Verwenden
1-Fluoro-2,4-dinitrobenzene is used to identify the amino acid sequence. It reacts with amino group of amino acids to yield dinitrophenyl-amino acids. It is also used in chromatographic methods. Further, it acts as an alkylating agent used in elucidating amino acid sequence in proteins.
Definition
ChEBI: The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.
Allgemeine Beschreibung
Clear yellow crystals or yellow crystalline solid.
Air & Water Reaktionen
Slightly soluble in water.
Reaktivität anzeigen
Reacts with oxidizing agents . When air was admitted after vacuum evaporation of an ether peroxide solution, a violent explosion occurred. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.
Brandgefahr
2,4-Dinitrofluorobenzene is probably combustible.
Kontakt-Allergie
DNFB is a strong skin irritant and a universal contact allergen. It is used as an intermediate in the synthesis of pesticides and pharmaceuticals such as flurbiprofen, a chemical reagent, and as a topical sensitizer for the treatment of alopecia areata
Biochem/physiol Actions
1-Fluoro-2,4-dinitrobenzene is a contact-sensitizing hapten, commonly used in experimental studies on contact hypersensitivity, inducing itch model, and atopic dermatitis. Mast cell activation is a key step in the DNFB induced sensitivity. DNFB covalently binds to the N-terminal amino acid of the protein and aids in Sanger sequencing.
Sicherheitsprofil
Poison by ingestion,skin contact, and subcutaneous routes. A powerful irritant and vesicant. Mutation data reported. Solutions in ether may explode when evaporated* When heated to decomposition it emits highly toxic fumes of NOx and F-. See also NITRO E COMPOUNDS of AROMATIC HYDROCARBONS and FLUORIDES.
läuterung methode
Crystallise the reagent from Et2O or EtOH. Distil it in a vacuum through a Todd Column (p 11). If it is to be purified by distillation in vacuo, the distillation unit must be allowed to cool before air is allowed into the apparatus; otherwise the residue carbonises spontaneously and an EXPLOSION may occur. The material is a skin irritant and may cause serious dermatitis. [Beilstein 5 IV 742.]

2,4-Dinitrofluorobenzene Upstream-Materialien And Downstream Produkte

1-Fluor-2,4-dinitrobenzol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

70-34-8, 2,4-Dinitrofluorobenzene Verwandte Suche:

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